Inspired by nature, the bottom-up engineering of artificial cells has over the years emerged as an exciting research area to reconstruct and study key cellular hallmarks in a well-controlled, life-like environment. Researchers from the Department of Biomedical Engineering at TU/e and ICMS - Institute for Complex Molecular Systems Arjan Hazegh Nikroo, Wiggert Altenburg, Thijs Van Veldhuisen, Luc Brunsveld and Jan Van Hest published a new method for controlling protein release from artificial cells using light. 𝐏𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥 𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 💬 Studying how cells communicate with each other 💉 Developing new drug delivery methods 👩🔬 Creating more advanced artificial cell systems #latev #his #biomedicalengineering
Department of Biomedical Engineering at TU/e
Hoger onderwijs
Eindhoven, North Brabant 2.076 volgers
Education, research and valorization pertaining to technical solutions for medical problems.
Over ons
The Department of Biomedical Engineering is comprised of three clusters: Regenerative Engineering & Materials, Chemical Biology and Biomedical Imaging & Modelling. There are several research labs, for Cell & Tissue Engineering and for Biomechanics, to name a few. The department also closely collaborates with the Institute for Complex Molecular Systems.
- Website
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https://www.tue.nl/en/our-university/departments/biomedical-engineering/
Externe link voor Department of Biomedical Engineering at TU/e
- Branche
- Hoger onderwijs
- Bedrijfsgrootte
- 501 - 1.000 medewerkers
- Hoofdkantoor
- Eindhoven, North Brabant
- Type
- Erkende instelling
Locaties
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Primair
Eindhoven, North Brabant, NL
Medewerkers van Department of Biomedical Engineering at TU/e
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Steffie Hermans-Beijnsberger
Project development officer at Biomedical Engineering - Eindhoven University of Technology
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Daniëlle Duffhues
PhD candidate Biomedical Engineering @TU/e | Soft Tissue Engineering and Mechanobiology
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Meike Vermeulen
MSc student Biomedical Engineering & Science Education and Communication
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Micky Verhoeven
MSc Student Biomedical Engineering | Eindhoven University of Technology (TU/e) | Graduation 2025
Updates
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🧪A set of guidelines for navigating chemical space using AI has been published in Nature Computational Science last Friday, by researchers Derek van Tilborg and Francesca Grisoni from the Department of Biomedical Engineering at TU/e. While our vast cosmos contains an estimated 10²³ stars, there are an estimated 10⁶⁰ possible drug-like molecules in the “chemical universe”. Biological and chemical processes are extremely complex and discovering drugs for the hundreds of diseases that have no cure yet is time-consuming. Deep learning (AI) helps chemists navigate this immense “chemical universe” in a smarter way, accelerating drug discovery. 𝐀𝐜𝐭𝐢𝐯𝐞 𝐃𝐞𝐞𝐩 𝐋𝐞𝐚𝐫𝐧𝐢𝐧𝐠 Since the molecular data required to train these AI models is very scarce, Derek van Tilborg and Francesca Grisoni used active deep learning to get the most out of very little data. With this method, models actively decide which molecules to test and are then updated with this new molecular data. 𝐇𝐨𝐰 𝐥𝐨𝐰 𝐜𝐚𝐧 𝐲𝐨𝐮 𝐠𝐨? To stress-test active learning with little available data, van Tilborg and Grisoni trained models starting out with as few as two molecules in the most extreme scenario. They found that even with minimal initial data, active deep learning can enhance drug discovery efficiency. 𝐂𝐡𝐚𝐫𝐭𝐢𝐧𝐠 𝐜𝐡𝐞𝐦𝐢𝐜𝐚𝐥 𝐬𝐩𝐚𝐜𝐞 The set of five guidelines resulting from this comprehensive study may very well accelerate the shift towards fully automated, deep-learning-guided molecule screening, to discover better drugs with fewer resources. #ai #deepactivelearning #biomedicalengineering
Traversing chemical space with active deep learning for low-data drug discovery - Nature Computational Science
nature.com
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Department of Biomedical Engineering at TU/e heeft dit gerepost
Patients who underwent Roux-en-Y Gastric Bypass surgery for treatment of obesity or diabetes can suffer from post-bariatric hypoglycemia (PBH). It has been assumed that PBH is caused by increased levels of the hormone GLP-1. In this research, we elucidate the role of GLP-1 in PBH with a physiology-based mathematical model: https://lnkd.in/egWC9ZpN Work of Ysanne Pasveer of Department of Biomedical Engineering at TU/e with Ömrüm Aydin, Stijn Meijnikman, Bert Groen, Max Nieuwdorp MD PhD and Victor Gerdes of Amsterdam UMC
Does GLP-1 cause post-bariatric hypoglycemia: ‘Computer says no’
sciencedirect.com
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Pharmacies play a pivotal role in safe and efficient medicine use by patients. Recent laboratory results are indispensable for proper advice and guidance but are often unavailable or outdated. To address this issue Karin Haubrich designed a pilot process as part of the post-master program Qualified Medical Engineer (QME) to use so-called point-of-care tests in pharmacies for immediate on-site measurements and results. The project was carried out at SensUR Health. More information (Dutch) via the link below. #bme #qualifiedmedicalengineer #onsitemedicaltesting
Het ontwerp van een proces voor het point-of-care testen in de openbare apotheek
assets.w3.tue.nl
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While heart attacks may never completely become preventable, researchers from Catharina Hospital Eindhoven, Philips and the Department of Biomedical Engineering at TU/e have developed a smart data model that will save lives. 👇
While completely preventing heart attacks may never be possible, researchers from Catharina Hospital Eindhoven, Department of Biomedical Engineering at TU/e and Philips have developed a smart data model that will save lives as part of the COMBAT-VT project. 💓 By mining large amounts of patient data like precious diamonds, doctors can better assess who has a higher risk of life-threatening heart rhythm disorders after a heart attack. The project uses ten years of laboratory results, ECGs, and scans. Melissa Niemantsverdriet, working as a trainee of the post-master Qualified Medical Engineer (QME) program during the project, developed a system within COMBAT-VT that collects, structures, and analyzes large amounts of patient data. Frans van de Vosse, director of the QME program and professor of Cardiovascular Biomechanics at Eindhoven University of Technology, emphasizes the importance of presenting data in a way that actually supports healthcare professionals in their work. Cardiologist and TU/e part-time professor Lukas Dekker explains: "Hospitals need to think carefully about their data infrastructure for the future. And this requires both medical specialists and engineers." 🏥 Qualified Medical Engineers are crucial for the future of healthcare. The COMBAT-VT project demonstrates how collaboration between medical professionals and engineers can lead to innovative, life-saving, and affordable care. #medicalengineering #futureofhealthcare #bigdata
Project Catharina Ziekenhuis en de TU/e geeft meer inzicht in hartritmestoornissen ’Medische data zijn ruwe diamanten’
digimagazinefmtgezondheidszorg.nl
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While completely preventing heart attacks may never be possible, researchers from Catharina Hospital Eindhoven, Department of Biomedical Engineering at TU/e and Philips have developed a smart data model that will save lives as part of the COMBAT-VT project. 💓 By mining large amounts of patient data like precious diamonds, doctors can better assess who has a higher risk of life-threatening heart rhythm disorders after a heart attack. The project uses ten years of laboratory results, ECGs, and scans. Melissa Niemantsverdriet, working as a trainee of the post-master Qualified Medical Engineer (QME) program during the project, developed a system within COMBAT-VT that collects, structures, and analyzes large amounts of patient data. Frans van de Vosse, director of the QME program and professor of Cardiovascular Biomechanics at Eindhoven University of Technology, emphasizes the importance of presenting data in a way that actually supports healthcare professionals in their work. Cardiologist and TU/e part-time professor Lukas Dekker explains: "Hospitals need to think carefully about their data infrastructure for the future. And this requires both medical specialists and engineers." 🏥 Qualified Medical Engineers are crucial for the future of healthcare. The COMBAT-VT project demonstrates how collaboration between medical professionals and engineers can lead to innovative, life-saving, and affordable care. #medicalengineering #futureofhealthcare #bigdata
Project Catharina Ziekenhuis en de TU/e geeft meer inzicht in hartritmestoornissen ’Medische data zijn ruwe diamanten’
digimagazinefmtgezondheidszorg.nl
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🎉 We are thrilled to announce the NWO (Dutch Research Council) and public and private partners will invest a total budget of 54 million euros in a new world-leading innovation lab for radiotherapy and radiology. The IMAGINE consortium will develop image-guided techniques that allow doctors to ‘see wat they treat’, making cancer treatments more precise, better targeted and efficient. A special acknowledgement goes out to our colleagues at the Department of Biomedical Engineering at TU/e Josien Pluim, Steffie Hermans-Beijnsberger and Harmen de Jongh, and our colleagues at other departments Noortje Bax and Catarina Dinis Fernandes for making IMAGINE a reality. Also a huge thank you to alll partners for making this possible 🙏 💐 : UMC Utrecht, Utrecht University, Antoni van Leeuwenhoek, Radboudumc, Elekta, Philips, Eindhoven University of Technology, Centrum Wiskunde & Informatica, HU University of Applied Sciences Utrecht (Hogeschool Utrecht), Tesla Dynamic Coils, Fontys University of Applied Sciences, Catharina Hospital Eindhoven, De Haagse Hogeschool / The Hague University of Applied Sciences, KALCIO Healthcare, Lygature and Utrecht Inc. Make sure you read more in the link below👇. We'll be able to share more information on this exciting research soon.
🎉 IMAGINE becomes reality! NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek) and public and private partners will invest a total budget of 54 million euros (spread over ten years) in a new world-leading innovation lab for radiotherapy and radiology! 💪 The IMAGINE consortium speeds up the development, innovation and clinical introduction of image-guided, minimally invasive techniques, such as the MR-Linac. This will significantly improve the lives and healthcare of cancer patients. Image-guided techniques allow doctors to ‘see wat they treat’, making cancer treatments more precise, better targeted and efficient. IMAGINE will improve these innovative therapies even more by integrating the newest AI and data technologies. The 16 public and private partners will work side by side in a vibrant open innovation lab located at UMC Utrecht. There, AI developers, image scientists, methodologists, innovation experts, engineers, doctors and patients share knowledge, resources and ideas to invent and implement the newest imaging and image-guided technologies. With IMAGINE, the partners aim to achieve that: 💡 cancer patients will have faster access to the newest image-guided treatments. 💡 cancer patients can receive a minimally invasive treatment more often (instead of having surgery). 💡 the healthcare system will experience less pressure: the image-guided therapies are given in daycare, so less ORs, ICs and healthcare professionals will hopefully be needed. 💡 healthcare costs will be lower, for instance because drug treatment or hospitalization is often more expensive. 💡 healthcare professionals from various backgrounds will receive a future-proof education in an inspiring workplace. A huge thank you to @NWO and all public and private partners for making this possible 🙏 💐 : UMC Utrecht, Universiteit Utrecht, Antoni van Leeuwenhoek, Radboudumc, Elekta, Philips, Technische Universiteit Eindhoven, Centrum Wiskunde & Informatica , Hogeschool Utrecht, Tesla Dynamic Coils, Fontys Hogeschool, Catharina Ziekenhuis, De Haagse Hogeschool / The Hague University of Applied Sciences, KALCIO Healthcare, Lygature and @Utrecht Inc. 📖 Read more in the NWO announcement: https://lnkd.in/eZM6h_DX. ❗ Stay tuned for more detailed information about the IMAGINE consortium to follow soon, here and on the UMC Utrecht website. Cancer Research UMC Utrecht | Radiotherapie UMC Utrecht | Nico Van Den Berg | HM (Lenny) Verkooijen | Maarten van Kouwen | Lonneke van Reeuwijk | Jeroen Hendrikse | Elsken Van Der Wall #cancerresearch #mrlinac #radiotherapy #radiology #openinnovation Pictured below: Nico Van Den Berg, HM (Lenny) Verkooijen and Maarten van Kouwen.
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We are honoring the journey of Sander van den Borne, whose dedication to advancing mental health care through innovative technology is a powerful testament to the impact of personal experiences on research. Read more about his impressive story in the linked article below. Sander has developed a technological solution called the "Robin system", after his sister, to improve medication monitoring for patients with mental disorders. Sander defends his EngD thesis on September 20th at the school of medical physics and engineering Eindhoven, part of the Department of Biomedical Engineering at TU/e.
The family of EngD researcher Sander van den Borne know all too well about how a mental disorder can affect a family member. Sander’s sister Robin was diagnosed at an early age and lost her battle with mental disorders at just 19 years old. Motivated by his sister’s story, Sander, who is also a clinical informatician in training at Mental Healthcare Eindhoven (Geestelijke Gezondheidszorg Eindhoven or GGzE), has developed a technological solution to help doctors and institutes to monitor patients who are taking serious medication for mental disorders. Sander defends his EngD research on September 20th at the school of medical physics and engineering Eindhoven, which is part of the department of Biomedical Engineering. Read Sander and Robin's story👇 https://lnkd.in/g58rG6jP
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Congratulations to Miguel Castilho and Paula Vena and their collaborators at UMC Utrecht Martina Viola and Gerardo Cedillo-Servin for their groundbreaking work on #electrowriting aqueous #silkfibroin solutions! 🎉 𝗞𝗲𝘆 𝗔𝗰𝗵𝗶𝗲𝘃𝗲𝗺𝗲𝗻𝘁𝘀: • Developed a method to create 3D silk fibroin microstructures with precise control over molecular alignment and fiber organization • Successfully processed organized fiber scaffolds with flat and tubular shapes, achieving approximately 97% open porosity. • Demonstrated structures that support elastic cyclic loading up to 20% deformation. • Facilitated in vitro adherence and growth of human renal epithelial and endothelial cells, with over 95% viability. This collaborative effort between our Department of Biomedical Engineering at TU/e Eindhoven University of Technology, UMC Utrecht, and Utrecht University represents a significant advancement in regenerative medicine and biomaterials research. 𝗣𝗼𝘁𝗲𝗻𝘁𝗶𝗮𝗹 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀: • Tissue engineering • Regenerative medicine This team's approach is a significant development in fabricating organized stable silkfibroin scaffolds with unique microfiber structures and mechanical and biological properties that make them highly promising for tissue engineering applications.
Microstructured silk fiber scaffolds with enhanced stretchability
pubs.rsc.org
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💥 Exciting news in cancer medicine research using nanotechnology 🔍 The latest generation of cancer drugs uses immunotherapy. However, current treatments are not always effective and can potentially lead to adverse side effects for the patient. A collaboration of 30 scientists worldwide, with BmE professors Jan Van Hest and Willem Mulder leading the TU/e team, has made hopeful strides in using nanotechnology to stimulate the body's own immune system. TU/e scientists Annelies Wauters and Jari Scheerstra combined the best of both worlds by developing nanomedicines that can deliver immunotherapy at their target: nano-immunotherapy. 👨🔬 You can read more about it on the TU/e website: https://lnkd.in/e4YBYqT7 And in their newly published scientific article in Nature Nanotechnology: https://lnkd.in/eeeJWXvr 🔬 Research Highlights: · The creation of biodegradable polymer nanocarriers that target specific organs and cells of the immune system. · The nanocarriers can precisely deliver medication to immune cells in the spleen, a key player in our immune system. · Nanocarrier drug delivery results in specific activation of immune cells in the spleen, leading to anti-tumor effects in animal tests. This research marks a promising step towards more effective and patient-friendly cancer treatments. With continued development, the team hopes to bring a new generation of cancer medication to patients within the next 20 years. #CancerResearch #Immunotherapy #Nanotechnology