IMU Bioactive Molecules & Drug Delivery

Medication errors can have profound consequences, ranging from mild adverse reactions to life-threatening situations. These errors, often resulting from incorrect dosage, timing, or administration, highlight the critical need for precision and attention in healthcare settings. They can lead to increased patient morbidity, prolonged hospital stays, and higher healthcare costs, not to mention the emotional and physical toll on patients. Preventing medication errors requires a collaborative effort from healthcare providers, including clear communication, thorough documentation, and leveraging technology like electronic prescribing systems. A proactive approach can significantly reduce errors and improve patient outcomes, ensuring safer healthcare practices. #HealthcareSafety #MedicationErrors #PatientCare #Pharmaceuticals #PrecisionInHealthcare

Hemoglobin A1C (HgBA1c) testing is essential for effective diabetes management as it reflects average blood sugar levels over the past three months, offering a comprehensive view beyond one-time checks. Regular testing helps healthcare providers adjust treatment plans, reduce complications, and improve patient outcomes. For patients with stable glucose levels, testing twice a year is recommended, while those with treatment changes or unmet glycemic goals should test every three months. To enhance adherence, patient education, reminder systems, and making testing more accessible are key strategies for improving long-term diabetes control and overall health. Thanks @Sidikakarakas for sharing this useful information. #DiabetesManagement #HbA1c #PatientCare #Healthcare #ChronicDiseaseManagement #Endocrinology #DiabetesAwareness #HealthOutcomes #PreventiveCare #MedicalResearch

A new study in Cell shows Moderna’s investigational mpox vaccine, mRNA-1769, outperformed the current Jynneos vaccine in nonhuman primates. The mRNA vaccine resulted in significantly fewer lesions (54 vs. 607) and offers strong protection against mpox, especially as the WHO recently declared mpox a public health emergency again. #Vaccines #Moderna #mpox #mRNA #PublicHealth #InfectiousDiseases #Research #GlobalHealth

Exploring the molecular mechanisms of aging, a recent study compares the effects of calorie restriction (CR) and rapamycin (RM) on protein phosphorylation in mouse muscles—an essential process in cell signaling. While CR improved body-mass-normalized soleus mass, RM showed a more significant impact on preventing the age-related decline in triceps mass. Interestingly, both interventions slow aging by modulating the mTORC1 pathway, though they differ in their muscle-type specificity. CR’s effects varied between muscle types, whereas RM exhibited more consistent results across different muscles. Although the clinical translation of these findings remains uncertain, understanding the distinct impacts of these two powerful lifespan-extending interventions is crucial for advancing aging research. #AgingResearch #mTORC1 #CalorieRestriction #Rapamycin #MuscleAging #ProteinPhosphorylation #LifespanExtension #CellSignaling #ScientificResearch

Unveiling the Cellular Mechanism of Fasting: Implications for Metabolic Health and Cancer Treatment Fasting has long been recognized for its health benefits, but recent findings provide insight into the cellular mechanisms behind these effects. During fasting, liver cells reduce overall protein synthesis, yet a critical protein, eIF4E, becomes phosphorylated (P-eIF4E), a key step in breaking down fats into ketone bodies. This process is initiated by increased fatty acids during fasting, which activate AMPK and MNK proteins, ultimately leading to the activation of P-eIF4E. Significantly, certain cancers, such as pancreatic cancer, can exploit ketone bodies as an energy source. A study demonstrated that blocking P-eIF4E with the drug eFT508 slows the growth of pancreatic tumors in mice on a ketogenic diet. This suggests that combining eIF4E inhibitors with a ketogenic diet could offer a novel approach to treating pancreatic cancer, a notoriously challenging malignancy. #Fasting #CellularMetabolism #CancerResearch #KetogenicDiet #PancreaticCancer #Metabolism #AMPK #eIF4E

Attention fellow chemists and researchers! Let’s talk about the secret sauce behind oral bioavailability for PROTACs. Molecular properties like solvent-exposed H-bond donors (eHBD), acceptors (eHBA), polarity, lipophilicity, and molecular weight are the VIPs in this game. And here’s the kicker: keeping eHBD ≤ 2 in apolar environments is like ensuring your molecular guests don’t overstay their welcome. It’s crucial for higher bioavailability. So, next time you’re in the lab, remember: it’s all about the right balance. Too many H-bond donors? Your compound might just be too clingy. #MedicinalChemistry #Bioavailability #PROTACs #ChemistryRocks #DrugDesign

A key challenge in precision medicine is identifying individuals at high risk of disease to enhance patient outcomes. Blood-based biomarkers offer early indicators of disease risk and onset, but there is a lack of biomarkers for predicting disease onset, leading to delayed diagnoses. Recent advancements in proteomic platforms now allow for the systematic identification of predictive biomarkers in a hypothesis-free manner. #PrecisionMedicine #Healthcare #Biomarkers

This paper will be the best educational resource for those who are interested in Medicinal chemistry and passionate to pursue their career innerug discovery.

Its amazing to see that there are about 750 names are in various phases of clinical trials sponsored by top 10 Pharma Giants in the year 2023