(Q73045053)

English

Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist

scientific article published on 01 November 2000

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11020444 AND SRC:MED&resulttype=core&format=json

31 October 2019

Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11020444 AND SRC:MED&resulttype=core&format=json

31 October 2019

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H S Ahn

1

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31 October 2019

C Foster

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11020444 AND SRC:MED&resulttype=core&format=json

31 October 2019

G Boykow

3

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31 October 2019

A Stamford

4

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31 October 2019

M Manna

5

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31 October 2019

M Graziano

6

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31 October 2019

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1 November 2000

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31 October 2019

Biochemical Pharmacology

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31 October 2019

60

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31 October 2019

10

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31 October 2019

1425-1434

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31 October 2019

Regulation of thrombin generation and functions

1 reference

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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Thrombin and proliferation of vascular smooth muscle cells

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7 January 2021

Thrombin and vascular smooth muscle cell proliferation: implications for atherosclerosis and restenosis

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7 January 2021

Molecular cloning of a potential proteinase activated receptor

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7 January 2021

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

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7 January 2021

Protease-activated receptor 3 is a second thrombin receptor in humans

1 reference

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7 January 2021

Cloning and characterization of human protease-activated receptor 4

1 reference

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7 January 2021

A dual thrombin receptor system for platelet activation

1 reference

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7 January 2021

Thrombin receptor expression in normal and atherosclerotic human arteries

1 reference

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7 January 2021

Characterization of thrombin receptor expression during vascular lesion formation

1 reference

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7 January 2021

Role of the thrombin receptor in restenosis and atherosclerosis

1 reference

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7 January 2021

An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey

1 reference

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7 January 2021

Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na /H exchange by a thrombin receptor antagonist

1 reference

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7 January 2021

Development of potent thrombin receptor antagonist peptides

1 reference

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7 January 2021

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

1 reference

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7 January 2021

Pharmacological characterization of protease-activated receptor (PAR-1) in rat astrocytes

1 reference

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7 January 2021

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif

1 reference

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7 January 2021

A novel molecular design of thrombin receptor antagonist

1 reference

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7 January 2021

Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1).

1 reference

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7 January 2021

A comparative SAR study of thrombin receptor derived non peptide mimetics: importance of phenyl/guanidino proximity for activity

1 reference

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7 January 2021

Binding of a thrombin receptor tethered ligand analogue to human platelet thrombin receptor

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7 January 2021

Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists

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7 January 2021

In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist

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7 January 2021

Platelet aggregation monitored in a 96 well microplate reader is useful for evaluation of platelet agonists and antagonists

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7 January 2021

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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7 January 2021

Ligand cross-reactivity within the protease-activated receptor family.

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7 January 2021

Induction of Vascular Smooth Muscle Cell Growth by Selective Activation of the Proteinase Activated Receptor-2 (PAR-2)

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7 January 2021

Evidence for proteinase-activated receptor-2 (PAR-2)-mediated mitogenesis in coronary artery smooth muscle cells

1 reference

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7 January 2021

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

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7 January 2021

The pathogenesis of atherosclerosis: a perspective for the 1990s

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Activation of NFkappaB is essential but not sufficient to stimulate mitogenesis of vascular smooth muscle cells

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The response of smooth muscle cells to alpha-thrombin depends on its arterial origin: comparison among different species

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Thrombin but not thrombin receptor activating peptide is mitogenic for coronary artery smooth muscle cells

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7 January 2021

Thrombin receptor antagonists: a work in progress.

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7 January 2021

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

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Therapeutic inhibition of thrombin activities, receptors, and production.

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7 January 2021

Identifiers

10.1016/S0006-2952(00)00460-3

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11020444 AND SRC:MED&resulttype=core&format=json

31 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11020444 AND SRC:MED&resulttype=core&format=json

31 October 2019

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