(Q5572289)

GPCR family 2, extracellular hormone receptor domain superfamily

1 reference

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.4.6

2 October 2019

hierarchical database ID heuristic

GPCR, family 2, extracellular hormone receptor domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

GPCR, family 2, secretin-like, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

G protein-coupled peptide receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43220&geneProductId=UniProtKB:P43220

1 reference

27 February 2018

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43220&geneProductId=UniProtKB:P43220

1 reference

27 February 2018

protein binding

IPI

1 reference

8 April 2019

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

glucagon receptor activity

IPI

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

1 reference

8 April 2019

glucagon-like peptide 1 receptor activity

1 reference

8 April 2019

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

peptide hormone binding

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

integral component of membrane

IBA

cell component

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

3 references

8 April 2019

8 April 2019

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

8 April 2019

intracellular anatomical structure

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43220&geneProductId=UniProtKB:P43220

integral component of plasma membrane

1 reference

8 April 2019

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

regulation of heart contraction

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

regulation of insulin secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

1 reference

8 April 2019

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

cellular response to glucagon stimulus

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

activation of adenylate cyclase activity

1 reference

8 April 2019

Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

cell surface receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

1 reference

8 April 2019

positive regulation of blood pressure

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43220&geneProductId=UniProtKB:P43220

learning or memory

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

cAMP-mediated signaling

1 reference

8 April 2019

Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

1 reference

8 April 2019

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

G protein-coupled receptor signaling pathway

response to psychosocial stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43220

physically interacts with

tirzepatide

object of statement has role

agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL4297839

dulaglutide

object of statement has role

agonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2108027

Gene Atlas image

PBB GE GLP1R 208401 s at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P43220

1 reference

1 reference

GPCR, family 2, extracellular hormone receptor domain

1 reference

GPCR, family 2, secretin-like, conserved site

1 reference

D12.776.543.750.695.021.500

Identifiers

MeSH descriptor ID

D000067757

subject named as

Glucagon-Like Peptide-1 Receptor

0 references

MeSH tree code

0 references

D12.776.543.750.750.360.100.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

9.A.14.4.6

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023