(Q54652087)

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4 January 2020

title

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling (English)

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4 January 2020

1

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4 January 2020

Louise M. Judd

12

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4 January 2020

Alex Boussioutas

14

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4 January 2020

Rachel M McLoughlin

8

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4 January 2020

Simon Jones

9

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4 January 2020

Matthias Ernst

16

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4 January 2020

author name string

Dianne Grail

2

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4 January 2020

Thao Nheu

3

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4 January 2020

Meri Najdovska

4

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4 January 2020

Bo Wang

5

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4 January 2020

Paul Waring

6

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4 January 2020

Melissa Inglese

7

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4 January 2020

Nicholas Topley

10

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4 January 2020

Heinz Baumann

11

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4 January 2020

Andrew S Giraud

13

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4 January 2020

Hong-Jian Zhu

15

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4 January 2020

language of work or name

English

0 references

publication date

24 July 2005

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4 January 2020

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4 January 2020

volume

11

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4 January 2020

issue

8

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4 January 2020

page(s)

845-852

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The STAT3 isoforms alpha and beta have unique and specific functions

4 January 2020

cites work

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7 January 2021

1 reference

7 January 2021

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

1 reference

7 January 2021

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

1 reference

7 January 2021

SOCS3 negatively regulates IL-6 signaling in vivo

1 reference

7 January 2021

Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein

1 reference

7 January 2021

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

7 January 2021

TGFbeta signaling in growth control, cancer, and heritable disorders

1 reference

7 January 2021

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

1 reference

7 January 2021

Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene

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7 January 2021

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis

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7 January 2021

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

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7 January 2021

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.

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7 January 2021

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

1 reference

7 January 2021

Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

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7 January 2021

Acquiring signalling specificity from the cytokine receptor gp130.

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7 January 2021

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7 January 2021

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

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7 January 2021

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

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7 January 2021

Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways

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7 January 2021

Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway

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7 January 2021

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

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7 January 2021

STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.

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7 January 2021

The two histological main types of gastric carcinoma: diffuse and so called intestinal-type carcinoma: an attempt at a histo-clinical classification

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7 January 2021

Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer

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7 January 2021

Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.

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7 January 2021

Causal relationship between the loss of RUNX3 expression and gastric cancer

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7 January 2021

Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia

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7 January 2021

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

1 reference

7 January 2021

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

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7 January 2021

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

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7 January 2021

The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis

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7 January 2021

STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the α2-macroglobulin gene

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7 January 2021

Transcription factors as targets for cancer therapy

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7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

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7 January 2021

Receptor subunit-specific action of oncostatin M in hepatic cells and its modulation by leukemia inhibitory factor

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7 January 2021

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

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7 January 2021

Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter

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7 January 2021

Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression

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7 January 2021

Identifiers

DOI

10.1038/NM1282

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16041381 AND SRC:MED&resulttype=core&format=json

4 January 2020

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