(Q53644203)

16 May 2018

title

The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. (English)

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3

Jan M van Deursen

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author name string

Karthik B Jeganathan

series ordinal

1

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Liviu Malureanu

series ordinal

2

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language of work or name

English

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publication date

1 December 2005

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16 May 2018

published in

Nature

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volume

438

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issue

7070

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page(s)

1036-1039

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The anaphase-promoting complex: proteolysis in mitosis and beyond

cites work

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Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

21 January 2018

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RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains

21 January 2018

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The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins

21 January 2018

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The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

21 January 2018

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Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

21 January 2018

1 reference

Identification and characterization of nuclear pore subcomplexes in mitotic extract of human somatic cells

21 January 2018

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A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly

21 January 2018

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Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

21 January 2018

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Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

21 January 2018

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Securin is required for chromosomal stability in human cells

21 January 2018

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Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts

21 January 2018

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Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis

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Recycling the Cell Cycle

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Regulation of APC activity by phosphorylation and regulatory factors

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Mitotic regulation of the APC activator proteins CDC20 and CDH1

21 January 2018

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Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

21 January 2018

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CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

21 January 2018

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

21 January 2018

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Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex

21 January 2018

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Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NATURE04221

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16 May 2018

Dimensions Publication ID

1034456069

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16 May 2018