(Q53334281)

13 May 2018

title

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. (English)

1 reference

13 May 2018

author name string

Christopher J Sarkisian

1

1 reference

13 May 2018

Blaine A Keister

2

1 reference

13 May 2018

Douglas B Stairs

3

1 reference

13 May 2018

Robert B Boxer

4

1 reference

13 May 2018

Susan E Moody

5

1 reference

13 May 2018

Lewis A Chodosh

6

1 reference

13 May 2018

publication date

22 April 2007

1 reference

13 May 2018

published in

Nature Cell Biology

1 reference

13 May 2018

volume

9

1 reference

13 May 2018

issue

5

1 reference

13 May 2018

page(s)

493-505

1 reference

13 May 2018

Creation of human tumour cells with defined genetic elements

cites work

1 reference

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

1 reference

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

1 reference

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

21 January 2018

1 reference

BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

1 reference

Tumour biology: senescence in premalignant tumours

21 January 2018

1 reference

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

21 January 2018

1 reference

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

1 reference

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1

21 January 2018

1 reference

A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology

21 January 2018

1 reference

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

21 January 2018

1 reference

The activation of phosphatidylinositol 3-kinase by Ras

21 January 2018

1 reference

AP-1 in cell proliferation and survival

21 January 2018

1 reference

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways.

21 January 2018

1 reference

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

21 January 2018

1 reference

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

21 January 2018

1 reference

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

21 January 2018

1 reference

Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

21 January 2018

1 reference

Induction of senescence by oncogenic Ras.

21 January 2018

1 reference

Microarray analysis of replicative senescence

21 January 2018

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

21 January 2018

1 reference

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

1 reference

Oncogenic ras and p53 cooperate to induce cellular senescence

21 January 2018

1 reference

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

21 January 2018

1 reference

hCDC47, a Human Member of the MCM Family

21 January 2018

1 reference

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

1 reference

Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesis

21 January 2018

1 reference

Predisposition to neoplastic transformation caused by gene replacement of H-ras1.

21 January 2018

1 reference

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

21 January 2018

1 reference

Gene expression analysis of urethane-induced lung tumors in ras H2 mice.

21 January 2018

1 reference

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

21 January 2018

1 reference

The ras gene family and human carcinogenesis

21 January 2018

1 reference

RAS is regulated by the let-7 microRNA family

21 January 2018

1 reference

Essential role for oncogenic Ras in tumour maintenance

21 January 2018

1 reference

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

21 January 2018

1 reference

The serine/threonine kinase, Krct, affects endbud morphogenesis during murine mammary gland development

21 January 2018

1 reference

Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals

21 January 2018

1 reference

Species- and cell type-specific requirements for cellular transformation

21 January 2018

1 reference

7 January 2021

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

7 January 2021

Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population

1 reference

7 January 2021

hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase

1 reference

7 January 2021

c-K-ras overexpression is characteristic for metastases derived from a methylcholanthrene-induced fibrosarcoma.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NCB1567

1 reference

13 May 2018

1 reference

13 May 2018