Wikidata

(Q5049052)

English

Caspase 1

mammalian protein found in Homo sapiens

  • Interleukin-1 beta convertase
  • interleukin 1, beta, convertase
  • ICE
  • p45
  • Interleukin-1 beta-converting enzyme
  • CASP1
  • IL-1BC
  • interleukin-1 β converting enzyme
  • IL-1 beta-converting enzyme
  • caspase 1, apoptosis-related cysteine peptidase
  • IL1B-convertase
  • caspase-1
  • CASP1 nirs variant 1
  • interleukin 1-B converting enzyme
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
21 references
retrieved
9 May 2019
stated in
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation
GOA
curator
UniProt
UniProt protein ID
P29466
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion
GOA
curator
UniProt
UniProt protein ID
P29466
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
SERPINB1-mediated checkpoint of inflammatory caspase activation
GOA
curator
UniProt
UniProt protein ID
P29466
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease
GOA
curator
UniProt
UniProt protein ID
P29466
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion
GOA
curator
UniProt
UniProt protein ID
P29466
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses
GOA
curator
UniProt
UniProt protein ID
P29466
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins
GOA
curator
UniProt
UniProt protein ID
P29466
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing
GOA
curator
UniProt
UniProt protein ID
P29466
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Active caspase-1 is a regulator of unconventional protein secretion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
retrieved
9 May 2019
stated in
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29466
cell component
biological process
EC enzyme number
3.4.22.36
0 references

Identifiers

MeSH term ID
T059969
0 references
MeSH concept ID
M0029892
0 references
PDB structure ID
 
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