(Q48567903)

12 February 2018

title

Engineering broader specificity into an antibiotic-producing polyketide synthase (English)

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12 February 2018

author

Peter Leadlay

6

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12 February 2018

author name string

Marsden AF

1

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12 February 2018

Wilkinson B

2

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12 February 2018

Cortés J

3

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12 February 2018

Dunster NJ

4

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12 February 2018

Staunton J

5

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12 February 2018

language of work or name

English

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publication date

1 January 1998

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12 February 2018

published in

Science

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12 February 2018

volume

279

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12 February 2018

issue

5348

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12 February 2018

page(s)

199-202

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12 February 2018

Antibiotic resistance: a view from the pharmaceutical industry

cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Drug-resistant bacteria: responding to the infectious disease crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Modular organization of genes required for complex polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Polyketide synthesis: prospects for hybrid antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Engineered biosynthesis of a complete macrolactone in a heterologous host

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Production of a novel polyketide through the construction of a hybrid polyketide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

In vivo and in vitro effects of thiolactomycin on fatty acid biosynthesis in Streptomyces collinus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Engineered biosynthesis of novel polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Evidence for a double-helical structure for modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

Combinatorial approaches to polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

21 January 2018

Bacteria on the rampage

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.279.5348.199

10.1126/SCIENCE.279.5348.199

21 January 2018

Identifiers

DOI

1 reference

12 February 2018

1 reference

12 February 2018