(Q47196688)

11 January 2018

title

Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors (English)

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11 January 2018

traditional Chinese medicine

main subject

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object named as

traditional Chinese medicine

17 February 2024

1

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11 January 2018

Wolfgang Meyerhof

5

object named as

Wolfgang Meyerhof

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11 January 2018

author name string

Ming Gu

2

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11 January 2018

Shengjie Fan

3

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11 January 2018

Cheng Huang

4

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11 January 2018

publication date

21 August 2017

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11 January 2018

Chemical Biology and Drug Design

published in

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11 January 2018

A novel family of mammalian taste receptors

cites work

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T2Rs function as bitter taste receptors

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A family of candidate taste receptors in human and mouse

21 January 2018

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Adaptive diversification of bitter taste receptor genes in Mammalian evolution

21 January 2018

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The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

21 January 2018

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Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol

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Functions of human bitter taste receptors depend on N-glycosylation

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Structural requirements of bitter taste receptor activation

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The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.

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The cell biology of taste

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Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells.

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Is the bitter rejection response always adaptive?

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Ruminant self-medication against gastrointestinal nematodes: evidence, mechanism, and origins

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Use of Vernonia amygdalina by wild chimpanzee: possible roles of its bitter and related constituents.

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Gustatory and extragustatory functions of mammalian taste receptors

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Where is the hope for drug discovery? Let history tell the future.

21 January 2018

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The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

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Pharmacokinetic behavior of gentiopicroside from decoction of Radix Gentianae, Gentiana macrophylla after oral administration in rats: a pharmacokinetic comaprison with gentiopicroside after oral and intravenous administration alone

21 January 2018

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Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes

21 January 2018

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Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans

21 January 2018

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Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium.

21 January 2018

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The human taste receptor hTAS2R14 responds to a variety of different bitter compounds

21 January 2018

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The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin

21 January 2018

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Characterization and Modulation of the Bitterness of Polymethoxyflavones Using Sensory and Receptor-Based Methods

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The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

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Bitter and sweet taste receptors in the respiratory epithelium in health and disease

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Taste perception: from the tongue to the testis

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Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart.

21 January 2018

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Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart

21 January 2018

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Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model

21 January 2018

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Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem

21 January 2018

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Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain

21 January 2018

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TAS2R bitter taste receptors regulate thyroid function

21 January 2018

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Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.

21 January 2018

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Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes

21 January 2018

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Impact of bitter taste on gastric motility

21 January 2018

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Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans.

21 January 2018

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Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation

21 January 2018

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Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents

21 January 2018

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Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying

21 January 2018

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Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine

21 January 2018

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Chloroquine stimulates Cl- secretion by Ca2 activated Cl- channels in rat ileum

21 January 2018

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Chemesthesis and the Chemical Senses as Components of a "Chemofensor Complex"

21 January 2018

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The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study

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Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice

21 January 2018

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Stimulation of insulin secretion by denatonium, one of the most bitter-tasting substances known

21 January 2018

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Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance

21 January 2018

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The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14.

21 January 2018

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Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception.

21 January 2018

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Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine

21 January 2018

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Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3.

21 January 2018

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BitterDB: a database of bitter compounds

21 January 2018

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Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways

21 January 2018

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Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon

21 January 2018

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The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception

21 January 2018

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Bitter taste receptors influence glucose homeostasis

21 January 2018

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Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells

21 January 2018

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Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor.

21 January 2018

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Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/CBDD.13089

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11 January 2018

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11 January 2018