(Q46760824)

25 December 2017

title

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice (English)

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25 December 2017

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Mendez MJ

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Green LL

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Corvalan JR

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Jia XC

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Maynard-Currie CE

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Yang XD

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Gallo ML

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Louie DM

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Lee DV

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Erickson KL

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Luna J

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Roy CM

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Abderrahim H

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Kirschenbaum F

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Noguchi M

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Smith DH

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Fukushima A

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Hales JF

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Klapholz S

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Finer MH

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Davis CG

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Zsebo KM

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Jakobovits A

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25 December 2017

language of work or name

English

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publication date

1 February 1997

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25 December 2017

published in

Nature Genetics

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25 December 2017

volume

15

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issue

2

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page(s)

146-156

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25 December 2017

The human immunoglobulin VH repertoire

cites work

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The human immunoglobulin kappa locus consists of two copies that are organized in opposite polarity

21 January 2018

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Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

21 January 2018

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Analysis of the structural integrity of YACs comprising human immunoglobulin genes in yeast and in embryonic stem cells

21 January 2018

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Germ-line transmission and expression of a human-derived yeast artificial chromosome

21 January 2018

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Mutation of Leu25and Val27Introduces CC Chemokine Activity into Interleukin-8

21 January 2018

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Antigen-specific human antibodies from mice comprising four distinct genetic modifications

21 January 2018

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A directory of human germ-line V kappa segments reveals a strong bias in their usage

21 January 2018

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7 January 2021

Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

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7 January 2021

A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins

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7 January 2021

The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci

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7 January 2021

YAC vectors. Humanizing the mouse genome

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7 January 2021

Strategies for expressing human antibody repertoires in transgenic mice

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7 January 2021

High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice

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7 January 2021

Human immunoglobulin heavy-chain minilocus recombination in transgenic mice: gene-segment use in mu and gamma transcripts

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7 January 2021

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.

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7 January 2021

Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene

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7 January 2021

Reconstruction of the 2.4 Mb human DMD-gene by homologous YAC recombination

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7 January 2021

The human immunoglobulin kappa locus. Characterization of the partially duplicated L regions

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7 January 2021

Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production

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7 January 2021

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes

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7 January 2021

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences

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7 January 2021

Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes

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7 January 2021

Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody

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7 January 2021

Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library

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7 January 2021

Isolation of single-copy human genes from a library of yeast artificial chromosome clones

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7 January 2021

Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents

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7 January 2021

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus

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7 January 2021

Construction of yeast artificial chromosome libraries with large inserts using fractionation by pulsed-field gel electrophoresis

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7 January 2021

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

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7 January 2021

Rescue of end fragments of yeast artificial chromosomes by homologous recombination in yeast

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7 January 2021

Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, epsilon and alpha genes

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7 January 2021

The mouse IgH 3'-enhancer

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7 January 2021

Generation of a fusion partner to sample the repertoire of splenic B cells destined for apoptosis

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7 January 2021

1 Preparation of monoclonal antibodies: Strategies and procedures

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7 January 2021

Identifiers

DOI

10.1038/NG0297-146

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25 December 2017

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25 December 2017