(Q45932252)

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2 February 2020

title

Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms (English)

1 reference

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2 February 2020

1 reference

iron deficiency anemia

1 reference

1 reference

2

1 reference

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2 February 2020

Carlos López Otín

9

1 reference

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2 February 2020

Mayka Sánchez

3

1 reference

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2 February 2020

Gloria Velasco

8

1 reference

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2 February 2020

4

Cecilia Garabaya

1 reference

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2 February 2020

author name string

Andrew J Ramsay

1

1 reference

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2 February 2020

María P Sardà

5

1 reference

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2 February 2020

Montserrat Baiget

6

1 reference

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2 February 2020

Angel Remacha

7

1 reference

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2 February 2020

publication date

10 July 2009

1 reference

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2 February 2020

published in

Human Molecular Genetics

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2 February 2020

volume

18

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2 February 2020

issue

19

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2 February 2020

page(s)

3673-3683

1 reference

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Human and mouse proteases: a comparative genomic approach

2 February 2020

cites work

1 reference

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1 reference

Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes

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Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

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Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs).

21 January 2018

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Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains

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Hypertension in mice lacking the proatrial natriuretic peptide convertase corin

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Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss

21 January 2018

1 reference

An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss

21 January 2018

1 reference

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins

21 January 2018

1 reference

Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues

21 January 2018

1 reference

The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles

21 January 2018

1 reference

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

21 January 2018

1 reference

Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis

21 January 2018

1 reference

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 January 2018

1 reference

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

21 January 2018

1 reference

The serine protease TMPRSS6 is required to sense iron deficiency

21 January 2018

1 reference

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

21 January 2018

1 reference

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

21 January 2018

1 reference

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

21 January 2018

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Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

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Regulation of iron metabolism by hepcidin

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1 reference

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

21 January 2018

1 reference

A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron

21 January 2018

1 reference

Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

21 January 2018

1 reference

Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin

21 January 2018

1 reference

Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia

21 January 2018

1 reference

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21 January 2018

1 reference

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21 January 2018

1 reference

Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain

21 January 2018

1 reference

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

21 January 2018

1 reference

Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin

21 January 2018

1 reference

Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide

21 January 2018

1 reference

The Activation of Matriptase Requires Its Noncatalytic Domains, Serine Protease Domain, and Its Cognate Inhibitor

21 January 2018

1 reference

N-terminal processing is essential for release of epithin, a mouse type II membrane serine protease

21 January 2018

1 reference

Filamin is essential for shedding of the transmembrane serine protease, epithin

21 January 2018

1 reference

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

21 January 2018

1 reference

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

21 January 2018

1 reference

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

21 January 2018

1 reference

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

21 January 2018

1 reference

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

21 January 2018

1 reference

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

21 January 2018

1 reference

Clustal W and Clustal X version 2.0

21 January 2018

1 reference