(Q44542540)

4 December 2017

title

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages (English)

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4 December 2017

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endoplasmic reticulum

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10

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4 December 2017

12

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4 December 2017

Heather P Harding

6

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author name string

Bo Feng

1

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4 December 2017

Pin Mei Yao

2

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4 December 2017

Yankun Li

3

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4 December 2017

Cecilia M Devlin

4

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4 December 2017

Dajun Zhang

5

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4 December 2017

Michele Sweeney

7

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4 December 2017

James X Rong

8

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4 December 2017

George Kuriakose

9

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4 December 2017

Andrew R Marks

11

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4 December 2017

Ira Tabas

13

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4 December 2017

publication date

10 August 2003

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4 December 2017

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4 December 2017

volume

5

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4 December 2017

issue

9

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4 December 2017

page(s)

781-792

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Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis

4 December 2017

cites work

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7 January 2021

Histochemical detection and differentiation of free and esterified cholesterol in swine atherosclerosis using filipin

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7 January 2021

Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma

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7 January 2021

Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages

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7 January 2021

Consequences of cellular cholesterol accumulation: basic concepts and physiological implications

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7 January 2021

Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death

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7 January 2021

Free cholesterol loading of macrophages induces apoptosis involving the fas pathway.

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7 January 2021

Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway

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7 January 2021

Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane

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7 January 2021

Modulation of membrane function by cholesterol.

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7 January 2021

Cholesterol and the Golgi apparatus

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7 January 2021

Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals

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7 January 2021

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

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7 January 2021

Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine bios

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7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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7 January 2021

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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7 January 2021

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

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7 January 2021

Niemann-Pick disease type C

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7 January 2021

ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity

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7 January 2021

Cellular cholesterol efflux mediated by cyclodextrins. Demonstration Of kinetic pools and mechanism of efflux.

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7 January 2021

Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolism

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7 January 2021

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

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7 January 2021

Perk is essential for translational regulation and cell survival during the unfolded protein response

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7 January 2021

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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7 January 2021

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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7 January 2021

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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7 January 2021

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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7 January 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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7 January 2021

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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7 January 2021

Regulation of the endoplasmic reticulum calcium storage during the unfolded protein response--significance in tissue ischemia?

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7 January 2021

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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7 January 2021

The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

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7 January 2021

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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7 January 2021

Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles

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7 January 2021

Quantitation of the pool of cholesterol associated with acyl-CoA:cholesterol acyltransferase in human fibroblasts

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7 January 2021

The properties of mitochondria enriched in vitro with cholesterol

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7 January 2021

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts

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7 January 2021

Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice

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7 January 2021

Identifiers

DOI

10.1038/NCB1035

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4 December 2017

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