(Q43764112)

English

Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).

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Europe PubMed Central

PubMed publication ID

26 November 2017

Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035). (English)

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26 November 2017

protein structure

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crystal structure

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author name string

M Stockley

1

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26 November 2017

W Clegg

2

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26 November 2017

G Fontana

3

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Europe PubMed Central

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26 November 2017

B T Golding

4

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26 November 2017

N Martin

5

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26 November 2017

L J Rigoreau

6

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26 November 2017

G C Smith

7

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26 November 2017

R J Griffin

8

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26 November 2017

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publication date

1 November 2001

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26 November 2017

number of pages

5

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Bioorganic & Medicinal Chemistry Letters

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26 November 2017

11

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26 November 2017

21

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26 November 2017

2837-2841

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Europe PubMed Central

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26 November 2017

The DNA-dependent protein kinase

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Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage

1 reference

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Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016/S0960-894X(01)00537-6

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based on heuristic

inferred from DOI database lookup

OK-1035, a selective inhibitor of DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016/S0960-894X(01)00537-6

7 January 2021

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DNA-dependent protein kinase inhibitor (OK-1035) suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin

1 reference

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Bipyridine cardiotonics: the three-dimensional structures of amrinone and milrinone

1 reference

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N-methoxy-n-methylamides as effective acylating agents

1 reference

https://api.crossref.org/works/10.1016/S0960-894X(01)00537-6

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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

https://api.crossref.org/works/10.1016/S0960-894X(01)00537-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1 reference

https://api.crossref.org/works/10.1016/S0960-894X(01)00537-6

7 January 2021

based on heuristic

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Identifiers

10.1016/S0960-894X(01)00537-6

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 November 2017

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