(Q42440126)

English

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

scientific article published on April 21, 2003

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Europe PubMed Central

PubMed publication ID

31 October 2017

Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice (English)

1 reference

10.1074/JBC.M300636200

https://api.crossref.org/works/10.1074/JBC.M300636200

26 December 2023

1 reference

10.1074/JBC.M300636200

https://api.crossref.org/works/10.1074/JBC.M300636200

26 December 2023

1 reference

10.1074/JBC.M300636200

https://api.crossref.org/works/10.1074/JBC.M300636200

26 December 2023

author name string

Bing Zheng

2

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Europe PubMed Central

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31 October 2017

Xu Shi-wen

4

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Europe PubMed Central

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31 October 2017

Ivan Fisher

6

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Europe PubMed Central

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31 October 2017

Konstantinos Lazaridis

7

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31 October 2017

Benoit de Crombrugghe

10

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Europe PubMed Central

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31 October 2017

Christopher P. Denton

1

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:12707256

26 December 2023

Lowri A. Evans

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:12707256

26 December 2023

Voon H. Ong

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:12707256

26 December 2023

David J. Abraham

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:12707256

26 December 2023

Carol M. Black

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:12707256

26 December 2023

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publication date

21 April 2003

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Europe PubMed Central

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31 October 2017

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http://www.jbc.org/article/S0021925820869762/pdf

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Europe PubMed Central

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26 December 2023

https://api.elsevier.com/content/article/PII:S0021925820869762?httpAccept=text/xml

1 reference

10.1074/JBC.M300636200

https://api.crossref.org/works/10.1074/JBC.M300636200

26 December 2023

https://api.elsevier.com/content/article/PII:S0021925820869762?httpAccept=text/plain

1 reference

10.1074/JBC.M300636200

https://api.crossref.org/works/10.1074/JBC.M300636200

26 December 2023

https://syndication.highwire.org/content/doi/10.1074/jbc.M300636200

1 reference

10.1074/JBC.M300636200

https://api.crossref.org/works/10.1074/JBC.M300636200

26 December 2023

Journal of Biological Chemistry

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31 October 2017

278

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31 October 2017

27

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Europe PubMed Central

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31 October 2017

25109-25119

1 reference

Europe PubMed Central

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31 October 2017

Biology of TGF-beta in knockout and transgenic mouse models

1 reference

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TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

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TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

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The dopamine β-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice

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Construction of a bifunctional mRNA in the mouse by using the internal ribosomal entry site of the encephalomyocarditis virus

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Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy

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Biomedical discovery with DNA arrays

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Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

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The androgen receptor represses transforming growth factor-beta signaling through interaction with Smad3.

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21 January 2018

Endoglin expression on human microvascular endothelial cells association with betaglycan and formation of higher order complexes with TGF-beta signalling receptors

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Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

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Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

1 reference

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21 January 2018

Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition

1 reference

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21 January 2018

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

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21 January 2018

Loss of TGF-beta signaling contributes to autoimmune pancreatitis

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21 January 2018

Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

1 reference

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21 January 2018

Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching

1 reference

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21 January 2018

Absence of proximal duct apoptosis in the ventral prostate of transgenic mice carrying the C3(1)-TGF-beta type II dominant negative receptor.

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21 January 2018

Hepatocellular expression of a dominant-negative mutant TGF-beta type II receptor accelerates chemically induced hepatocarcinogenesis

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Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor

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21 January 2018

Regulation of transforming growth factor-beta signaling

1 reference

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21 January 2018

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

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21 January 2018

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

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21 January 2018

Deficient Smad7 expression: a putative molecular defect in scleroderma

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21 January 2018

Cytokine directed therapy in scleroderma: rationale, current status, and the future

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21 January 2018

Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis

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21 January 2018

Increased transcriptional activities of transforming growth factor beta receptors in scleroderma fibroblasts

1 reference

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21 January 2018

Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.

1 reference

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21 January 2018

Localisation of transforming growth factor beta1 and beta3 mRNA transcripts in normal and fibrotic human lung

1 reference

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21 January 2018

Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family

1 reference

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21 January 2018

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

1 reference

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21 January 2018

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

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The heart and pulmonary vasculature in scleroderma: clinical features and pathobiology

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Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

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A simple, rapid, and sensitive DNA assay procedure

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Increased Expression of TGF-β Receptors by Scleroderma Fibroblasts: Evidence for Contribution of Autocrine TGF-β Signaling to Scleroderma Phenotype

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Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors

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Mutations of bone morphogenetic protein receptor type II are not found in patients with pulmonary hypertension and underlying connective tissue diseases

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Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase

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Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

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Cancer Research

28

59

2861

author name string

Go

publication date

1999

1 reference

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Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice

38

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American Journal of Physiology

40

284

G525

author name string

Schramm

publication date

2003

1 reference

10.1074/JBC.M300636200

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26 December 2023

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

44

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26 December 2023

Identifiers

10.1074/JBC.M300636200

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 October 2017

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