(Q41183818)

27 September 2017

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title

Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints (English)

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27 September 2017

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Y Shiloh

1

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27 September 2017

G Rotman

series ordinal

2

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27 September 2017

publication date

1 September 1996

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Journal of Clinical Immunology

27 September 2017

published in

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27 September 2017

volume

16

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27 September 2017

issue

5

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27 September 2017

page(s)

254-260

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Flow cytometric analysis of X-ray sensitivity in ataxia telangiectasia

27 September 2017

cites work

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Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast

21 January 2018

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Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

21 January 2018

1 reference

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

21 January 2018

1 reference

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

21 January 2018

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Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

21 January 2018

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Radiosensitivity in ataxia-telangiectasia

21 January 2018

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12 December 2020

Telomere reduction in human colorectal carcinoma and with ageing

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12 December 2020

The genetics of cell cycle checkpoints

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12 December 2020

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

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12 December 2020

Protein kinases and DNA damage

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12 December 2020

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I

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12 December 2020

In vitro phenotype of ataxia-telangiectasia (AT) fibroblast strains: clues to the nature of the "AT DNA lesion" and the molecular defect in AT

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12 December 2020

Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

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12 December 2020

Cell cycle control and cancer

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12 December 2020

Cancer risks in A-T heterozygotes

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12 December 2020

Identification of ataxia telangiectasia heterozygotes by flow cytometric analysis of X-ray damage

1 reference

12 December 2020

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1 reference

12 December 2020

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

12 December 2020

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12 December 2020

Fission yeast genes involved in coupling mitosis to completion of DNA replication

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12 December 2020

Yeast checkpoint genes in DNA damage processing: implications for repair and arrest

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12 December 2020

Clonal evolution of malignant and non-malignant T cells carrying t(14;14) and t(X;14) in patients with ataxia telangiectasia

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12 December 2020

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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12 December 2020

An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae

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12 December 2020

V(D)J recombination and ataxia-telangiectasia: a review

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12 December 2020

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells

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12 December 2020

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

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12 December 2020

Localization of an ataxia-telangiectasia gene to chromosome 11q22-23.

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12 December 2020

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

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12 December 2020

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells.

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12 December 2020

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

1 reference

12 December 2020

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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12 December 2020

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

1 reference

12 December 2020

The PI3-kinase serine kinase phosphorylates its p85 subunit and IRS-1 in PI3-kinase/IRS-1 complexes

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12 December 2020

Ataxia-telangiectasia: closer to unraveling the mystery

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12 December 2020

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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12 December 2020

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

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12 December 2020

Breast and other cancers in families with ataxia-telangiectasia

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12 December 2020

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

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12 December 2020

Control of p70 s6 kinase by kinase activity of FRAP in vivo

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12 December 2020

Incidence of cancer in 161 families affected by ataxia-telangiectasia

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12 December 2020

Heterogeneity of immunological abnormalities in ataxia-telangiectasia

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12 December 2020

Phosphatidylinositol 3-kinase

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12 December 2020

Abnormal response of ataxia-telangiectasia cells to agents that break the deoxyribose moiety of DNA via a targeted free radical mechanism.

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12 December 2020

DNA damage and the DNA-activated protein kinase

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12 December 2020

Ionizing radiation and cell cycle progression in ataxia telangiectasia.

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12 December 2020

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

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12 December 2020

A link between double-strand break-related repair and V(D)J recombination: the scid mutation

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12 December 2020

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1 reference

12 December 2020

Cell cycle dependence of mitotic delay in X-irradiated normal and ataxia-telangiectasia fibroblasts

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12 December 2020

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12 December 2020

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

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12 December 2020

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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12 December 2020

The cytogenetics of ataxia telangiectasia

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12 December 2020

On the nature of a defect in cells from individuals with ataxia-telangiectasia

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12 December 2020

Repair and Recombination: How to make ends meet

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12 December 2020

Cancers in 44 families with ataxia-telangiectasia

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12 December 2020

Hypersensitivity of Drosophila mei-41 mutants to hydroxyurea is associated with reduced mitotic chromosome stability

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12 December 2020

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

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12 December 2020

Clonal evolution of T-cell chronic lymphocytic leukaemia in a patient with ataxia telangiectasia

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12 December 2020

Genetic aspects of ataxia telangiectasia

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12 December 2020

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

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12 December 2020

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

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12 December 2020

V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder

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12 December 2020

Ataxia-telangiectasia and cellular responses to DNA damage.

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12 December 2020

Genomic Organization of the ATM gene

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12 December 2020

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

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12 December 2020

The rad3 gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair

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12 December 2020

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12 December 2020

DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

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12 December 2020

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe

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12 December 2020

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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12 December 2020

Genetic and cellular features of ataxia telangiectasia

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12 December 2020

Molecular analysis of a new translocation, t(X;14)(q28;q11), in premalignancy and in leukaemia associated with ataxia telangiectasia

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12 December 2020

Isolation and characterization of X-linked mutants of Drosophila melanogaster which are sensitive to mutagens

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12 December 2020

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM

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12 December 2020

Cell-cycle regulators and cancer

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12 December 2020

Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis

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12 December 2020

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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12 December 2020

Serum IgG subclass deficiency in ataxia-telangiectasia

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12 December 2020

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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12 December 2020

Telomeres shorten during ageing of human fibroblasts

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12 December 2020

Radiation checkpoints in model systems

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12 December 2020

Physical and Genetic Mapping at the ATA/ATC Locus on Chromosome 11q22-23.

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12 December 2020

Genetic and physical mapping of the ataxia-telangiectasia locus on chromosome 11q22-q23.

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12 December 2020

Defect in Radiation Signal Transduction in Ataxia-telangiectasia

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12 December 2020

Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia

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12 December 2020

Radiation checkpoints in model systems

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12 December 2020

Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia

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12 December 2020

Genetic and physical mapping of the ataxia-telangiectasia locus on chromosome Ilq22-q23.

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12 December 2020

V(D)J Recombination and ataxia-telangiectasia: a Review

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12 December 2020

Identifiers

DOI

10.1007/BF01541389

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Dimensions Publication ID

27 September 2017

1033242958

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