(Q40883659)

24 September 2017

title

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch (English)

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24 September 2017

8

Haass C

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24 September 2017

Capell A

1

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24 September 2017

Steiner H

2

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24 September 2017

Romig H

3

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24 September 2017

Keck S

4

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24 September 2017

Baader M

5

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24 September 2017

Grim MG

6

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24 September 2017

Baumeister R

7

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24 September 2017

publication date

1 April 2000

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24 September 2017

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24 September 2017

volume

2

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24 September 2017

issue

4

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24 September 2017

page(s)

205-211

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Translating cell biology into therapeutic advances in Alzheimer's disease

24 September 2017

cites work

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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7 January 2021

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

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7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

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7 January 2021

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Nuclear access and action of notch in vivo

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

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7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

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7 January 2021

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Structure and alternative splicing of the presenilin-2 gene

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7 January 2021

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

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7 January 2021

The presenilin genes: a new gene family involved in Alzheimer disease pathology

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7 January 2021

Presenilins and Alzheimer disease

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7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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7 January 2021

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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7 January 2021

Generation of amyloid β protein from its precursor is sequence specific

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

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7 January 2021

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

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7 January 2021

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

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7 January 2021

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

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7 January 2021

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

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7 January 2021

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

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7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

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7 January 2021

Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa

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7 January 2021

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

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7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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7 January 2021

Presenilins, processing of beta-amyloid precursor protein, and notch signaling.

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7 January 2021

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

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7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

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7 January 2021

Identifiers

DOI

10.1038/35008626

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24 September 2017

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