(Q40849898)

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Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

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Europe PubMed Central

PMC publication ID

24 September 2017

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production (English)

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

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author name string

Z Zhu

1

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

R J Homer

2

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Z Wang

3

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Q Chen

4

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

G P Geba

5

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

J Wang

6

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Y Zhang

7

1 reference

Europe PubMed Central

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24 September 2017

J A Elias

8

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

language of work or name

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publication date

1 March 1999

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Journal of Clinical Investigation

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Europe PubMed Central

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24 September 2017

103

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

779-788

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Eotaxin is required for the baseline level of tissue eosinophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Selective expression of an interleukin-12 receptor component by human T helper 1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Functional diversity of helper T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

The effect of antigen dose on CD4 T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

The cells of the tracheobronchial epithelium of the mouse: a quantitative light and electron microscope study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Recombinant human interleukin 5 is a selective activator of human eosinophil function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

New Insights into Airway Inflammation by Endobronchial Biopsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Inflammation and airway reactivity in asthma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Recent advances in pulmonary medicine (1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

24 September 2017

Production of Interleukin 13 by Alveolar Macrophages from Normal and Fibrotic Lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

25 September 2017

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

25 September 2017

The expanding universe of T-cell subsets: Th1, Th2 and more.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

25 September 2017

Interleukin-4 and interleukin-13 differentially regulate epithelial chloride secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

25 September 2017

The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

Airway goblet cell mucin: its structure and regulation of secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

Skin-homing, CLA memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA- memory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4 T cells, analyzed at the single-cell level

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

Epithelial interleukin-11. Regulation by cytokines, respiratory syncytial virus, and retinoic acid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

cis-acting elements that confer lung epithelial cell expression of the CC10 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

17 June 2018

The role of IL-13 and its receptor in allergy and inflammatory responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

19 August 2018

Comparison of the regulations by Th2-type cytokines of the arachidonic-acid metabolic pathway in human alveolar macrophages and monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

19 August 2018

A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

19 August 2018

Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

19 August 2018

A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

19 August 2018

Interleukin-13 is produced by activated human CD45RA and CD45RO T cells: modulation by interleukin-4 and interleukin-12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

19 August 2018

IL-5-deficient mice have a developmental defect in CD5 B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408149

19 August 2018

IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL/6)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of interleukin 4 and interleukin 13 production by interferon alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-13 expression at the sites of allergen challenge in patients with asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) is associated with endothelial VCAM-1 upregulation and expression of TNF-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-13 and interleukin-4 are coexpressed in atopic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A distinct role for interleukin-13 in Th2-cell-mediated immune responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD4 T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bronchial hyperresponsiveness in patients recovering from acute severe asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of CD4 T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mycobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokine and chemokine networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4 Alters Epithelial Cell Differentiation and Surfactant Homeostasis in the Postnatal Mouse Lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/10079098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI5909

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

24 September 2017

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