Wikidata

(Q408476)

English

BCL2 associated X, apoptosis regulator

mammalian protein found in Homo sapiens

  • BAX
  • bcl-2-like protein 4
  • bcl2-L-4
  • Baxdelta2G9
  • Baxdelta2G9omega
  • BCL2 associated X protein
  • BCL2-associated X protein omega
  • Baxdelta2omega
  • apoptosis regulator BAX
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
58 references
retrieved
8 April 2019
stated in
Humanin peptide suppresses apoptosis by interfering with Bax activation
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
IAN family critically regulates survival and development of T lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Humanin peptide suppresses apoptosis by interfering with Bax activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human nuclear clusterin mediates apoptosis by interacting with Bcl‐XL through C‐terminal coiled coil domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
The DNA-binding domain mediates both nuclear and cytosolic functions of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human Bop is a novel BH3-only member of the Bcl-2 protein family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
BAX activation is initiated at a novel interaction site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
An interconnected hierarchical model of cell death regulation by the BCL-2 family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
UV irradiation resistance‐associated gene suppresses apoptosis by interfering with BAX activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-XL inhibits membrane permeabilization by competing with Bax.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
SH3GLB, a new endophilin-related protein family featuring an SH3 domain
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Clusterin inhibits apoptosis by interacting with activated Bax
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
identical protein binding
determination method or standard
IPI
14 references
retrieved
8 April 2019
stated in
The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bcl-XL inhibits membrane permeabilization by competing with Bax.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Viral apoptosis is induced by IRF-3-mediated activation of Bax
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
retrieved
8 April 2019
stated in
Clusterin inhibits apoptosis by interacting with activated Bax
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IPI
cell component
cytosol
determination method or standard
IDA
IEA
TAS
8 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IEA
retrieved
8 April 2019
stated in
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
BOK and NOXA are essential mediators of p53-dependent apoptosis
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
mitochondrion
determination method or standard
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IEA
retrieved
8 April 2019
stated in
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
BOK and NOXA are essential mediators of p53-dependent apoptosis
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
MAP-1 is a mitochondrial effector of Bax.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
biological process
positive regulation of apoptotic process
determination method or standard
IBA
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IEA
retrieved
8 April 2019
stated in
Identification of novel regulators of apoptosis using a high-throughput cell-based screen.
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cell-based screening and validation of human novel genes associated with cell viability
GOA
curator
UniProt
UniProt protein ID
Q07812
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07812
determination method or standard
IBA
Gene Atlas image
PBB GE BAX 208478 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D051028
subject named as
bcl-2-Associated X Protein
0 references
Microsoft Academic ID
2780362710
0 references
2909544034
0 references
PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q408476&oldid=2245723213"