(Q40410776)

20 September 2017

title

Mutant PIK3CA promotes cell growth and invasion of human cancer cells (English)

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20 September 2017

0 references

1 reference

11

Bert Vogelstein

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Yardena Samuels

Yardena Samuels

1

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Victor Velculescu

Victor E Velculescu

12

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Luis Alberto Diaz Jr

Luis A Diaz

2

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Kenneth W. Kinzler

10

Kenneth W Kinzler

1 reference

20 September 2017

8

David L Huso

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20 September 2017

7

Carlo Rago

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20 September 2017

4

Jordan M Cummins

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20 September 2017

3

Oleg Schmidt-Kittler

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20 September 2017

Laura Delong

5

1 reference

20 September 2017

Ian Cheong

6

1 reference

20 September 2017

Christoph Lengauer

9

1 reference

20 September 2017

publication date

1 June 2005

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20 September 2017

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20 September 2017

volume

7

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20 September 2017

issue

6

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20 September 2017

page(s)

561-573

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describes a project that uses

20 September 2017

DLD-1 PIK3CA E545K KO

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HCT 116 PIK3CA H1047R KO

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cites work

Mutations of the BRAF gene in human cancer

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Quantitative monitoring of gene expression patterns with a complementary DNA microarray

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Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

The PI3K-PDK1 connection: more than just a road to PKB

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

The phosphoinositide 3-kinase pathway

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

The biology and clinical relevance of the PTEN tumor suppressor pathway

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

ARK5 is a tumor invasion-associated factor downstream of Akt signaling

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Using the transcriptome to annotate the genome

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

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24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Targeted transgene insertion into human chromosomes by adeno-associated virus vectors

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Pten is essential for embryonic development and tumour suppression

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

RAF/RAS oncogenes and mismatch-repair status

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Phosphoinositide kinases

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Serial analysis of gene expression

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

TRAIL and apoptosis induction by TNF-family death receptors.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Accessing genetic information with high-density DNA arrays.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Cancer. Addiction to oncogenes--the Achilles heal of cancer

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Tumour suppression: disruption of HAUSP gene stabilizes p53

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Nature's TRAIL--on a path to cancer immunotherapy

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Choosing anticancer drug targets in the postgenomic era.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

The PIK3CA gene is mutated with high frequency in human breast cancers.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Mutation of the PIK3CA gene in ovarian and breast cancer

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Prevalence of ras gene mutations in human colorectal cancers

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2005.05.014

Identifiers

DOI

10.1016/J.CCR.2005.05.014

1 reference

release_nynrskaio5eija67cttubbwdue

20 September 2017

Fatcat ID

1 reference

https://api.fatcat.wiki/v0/release/nynrskaio5eija67cttubbwdue

Fatcat

reference URL

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference