(Q40240774)

18 September 2017

title

Insertion of an arginine residue into the transmembrane segments corrects protein misfolding (English)

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18 September 2017

main subject

transmembrane protein

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author name string

Tip W Loo

series ordinal

1

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18 September 2017

M Claire Bartlett

series ordinal

2

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18 September 2017

David M Clarke

series ordinal

3

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18 September 2017

language of work or name

English

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publication date

22 August 2006

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

281

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18 September 2017

issue

40

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18 September 2017

page(s)

29436-29440

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

18 September 2017

cites work

1 reference

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

21 January 2018

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Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure

21 January 2018

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Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

21 January 2018

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The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator

21 January 2018

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Folding of CFTR is predominantly cotranslational

21 January 2018

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Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

21 January 2018

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Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels

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Calreticulin negatively regulates the cell surface expression of cystic fibrosis transmembrane conductance regulator.

21 January 2018

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Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis

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Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications.

21 January 2018

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

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Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

21 January 2018

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DNA sequencing with chain-terminating inhibitors

21 January 2018

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

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21 January 2018

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Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

21 January 2018

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Interaction of transported drugs with the lipid bilayer and P-glycoprotein through a solvation exchange mechanism

21 January 2018

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Permanent Activation of the Human P-glycoprotein by Covalent Modification of a Residue in the Drug-binding Site

21 January 2018

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The drug-binding pocket of the human multidrug resistance P-glycoprotein is accessible to the aqueous medium.

21 January 2018

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Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites

21 January 2018

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Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

21 January 2018

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

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The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

21 January 2018

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Missense mutations in transmembrane domains of proteins: phenotypic propensity of polar residues for human disease

21 January 2018

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Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

21 January 2018

1 reference

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Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.C600209200

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18 September 2017

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