(Q40028993)

16 September 2017

title

RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells (English)

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16 September 2017

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Hiroshi Doi

1

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16 September 2017

Kazumasa Okamura

2

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16 September 2017

Peter O Bauer

3

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16 September 2017

Yoshiaki Furukawa

4

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16 September 2017

Hideaki Shimizu

5

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16 September 2017

Masaru Kurosawa

6

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16 September 2017

Yoko Machida

7

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16 September 2017

Haruko Miyazaki

8

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16 September 2017

Kenichi Mitsui

9

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16 September 2017

Yoshiyuki Kuroiwa

10

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16 September 2017

Nobuyuki Nukina

11

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16 September 2017

language of work or name

English

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publication date

31 December 2007

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

issue

10

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16 September 2017

page(s)

6489-6500

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

16 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

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Pathogenesis of polyglutamine disorders: aggregation revisited

21 January 2018

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https://api.crossref.org/works/10.1074/JBC.M705306200

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Identification of ubiquitin-interacting proteins in purified polyglutamine aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Pro-apoptotic protein kinase C delta is associated with intranuclear inclusions in a transgenic model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Proteomics of polyglutamine aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Sodium channel beta4 subunit: down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Generation of prion transmission barriers by mutational control of amyloid conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Expansion of polyglutamine induces the formation of quasi-aggregate in the early stage of protein fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI ] prion in yeast and aggregation of Sup35 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Nucleated conformational conversion and the replication of conformational information by a prion determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

A huntingtin-associated protein enriched in brain with implications for pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Protein aggregation and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Kinesin transports RNA: isolation and characterization of an RNA-transporting granule

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074/JBC.M705306200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705306200

1 reference

16 September 2017

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