(Q39986517)

16 September 2017

title

Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease (English)

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16 September 2017

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Ji-Young Park

1

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16 September 2017

Seung R Paik

series ordinal

2

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16 September 2017

Ilo Jou

series ordinal

3

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16 September 2017

Sang Myun Park

series ordinal

4

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16 September 2017

publication date

1 August 2008

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16 September 2017

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16 September 2017

volume

56

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16 September 2017

issue

11

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16 September 2017

page(s)

1215-1223

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Mechanisms of phagocytosis in macrophages

16 September 2017

cites work

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Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein

21 January 2018

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Alpha-synuclein expression modulates microglial activation phenotype

21 January 2018

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Oligomeric alpha-synuclein inhibits tubulin polymerization

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Fibrillar prion peptide (106-126) and scrapie prion protein hamper phagocytosis in microglia

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

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The biochemistry of Parkinson's disease

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Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

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A Drosophila model of Parkinson's disease

21 January 2018

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Brain dendritic cells and macrophages/microglia in central nervous system inflammation

21 January 2018

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Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease

21 January 2018

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Identification of two distinct synucleins from human brain

21 January 2018

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Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia

21 January 2018

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Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia

21 January 2018

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Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

21 January 2018

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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

21 January 2018

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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

21 January 2018

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Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

21 January 2018

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

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Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

21 January 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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Alpha-synuclein: normal function and role in neurodegenerative diseases.

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Oxidized glutathione stimulated the amyloid formation of alpha-synuclein

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Evidence that alpha-synuclein functions as a negative regulator of Ca( )-dependent alpha-granule release from human platelets

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

21 January 2018

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Chaperone-like activity of synucleins

21 January 2018

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α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

21 January 2018

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α-Synuclein in Lewy bodies

21 January 2018

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Microglia and neuroinflammation: a pathological perspective

21 January 2018

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Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein

21 January 2018

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Synoretin--A new protein belonging to the synuclein family

21 January 2018

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Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease

21 January 2018

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Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

21 January 2018

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α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

21 January 2018

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An inflammatory pathomechanism for Parkinson's disease?

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

21 January 2018

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Induction of neuronal death by α-synuclein

21 January 2018

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Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: mechanism for removal of apoptotic cells in the inflamed nervous system

21 January 2018

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7 January 2021

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

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7 January 2021

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

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7 January 2021

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

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7 January 2021

Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients

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7 January 2021

alpha-synuclein promotes mitochondrial deficit and oxidative stress

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7 January 2021

Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis

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7 January 2021

Structural changes in alpha-synuclein affect its chaperone-like activity in vitro

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7 January 2021

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7 January 2021

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

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7 January 2021

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

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7 January 2021

Identifiers

DOI

10.1002/GLIA.20691

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16 September 2017

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