(Q39341747)

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Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends

scientific article published on May 23, 2012

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Europe PubMed Central

PubMed publication ID

11 September 2017

Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends (English)

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Europe PubMed Central

PubMed publication ID

11 September 2017

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Anna Akhmanova

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Europe PubMed Central

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11 September 2017

Alessandra Pagano

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Alessandra Pagano

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Europe PubMed Central

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11 September 2017

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Stéphane Honoré

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Europe PubMed Central

PubMed publication ID

11 September 2017

Renu Mohan

3

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Europe PubMed Central

PubMed publication ID

11 September 2017

Raphael Berges

4

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11 September 2017

Diane Braguer

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11 September 2017

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23 May 2012

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11 September 2017

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https://api.elsevier.com/content/article/PII:S000629521200353X?httpAccept=text/xml

1 reference

10.1016/J.BCP.2012.05.010

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2 January 2025

https://api.elsevier.com/content/article/PII:S000629521200353X?httpAccept=text/plain

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10.1016/J.BCP.2012.05.010

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Biochemical Pharmacology

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Europe PubMed Central

PubMed publication ID

11 September 2017

84

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Europe PubMed Central

PubMed publication ID

11 September 2017

4

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Europe PubMed Central

PubMed publication ID

11 September 2017

432-443

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Europe PubMed Central

PubMed publication ID

11 September 2017

Antiangiogenic vinflunine affects EB1 localization and microtubule targeting to adhesion sites.

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Microtubule dynamics

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"Search-and-Capture" of Microtubules through Plus-End-Binding Proteins ( TIPs)

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CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulin-binding sites.

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Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells.

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Suppression of microtubule dynamic instability by the TIP protein EB1 and its modulation by the CAP-Gly domain of p150glued

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EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration

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Plus-end-tracking proteins and their interactions at microtubule ends

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Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development

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Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells.

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Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugs

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Desoxyepothilone B: An efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B

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10.1016/J.BCP.2012.05.010

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 September 2017

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