(Q38665423)

5 September 2017

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title

Rationale for the development of an engineered sporozoite malaria vaccine (English)

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5 September 2017

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2

Nussenzweig RS

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5 September 2017

Nussenzweig V

1

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5 September 2017

language of work or name

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1 January 1989

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5 September 2017

published in

Advances in Immunology

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5 September 2017

volume

45

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5 September 2017

page(s)

283-334

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Research toward malaria vaccines

5 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

THE IMMUNIZATION OF FOWLS AGAINST MOSQUITO-BORNE PLASMODIUM GALLINACEUM BY INJECTIONS OF SERUM AND OF INACTIVATED HOMOLOGOUS SPOROZOITES

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7 January 2021

Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei

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7 January 2021

Sporozoite-induced immunity in mammalian malaria. A review.

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7 January 2021

Comparative studies on the immunogenicity of infective and attenuated sporozoites of Plasmodium berghei

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Active immunization and passive transfer of resistance against sporozoite-induced malaria in infant mice

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Proceedings: The immunologic significance of the mammary gland

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites

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7 January 2021

Plasmodium vivax: Correlation of circumsporozoite precipitation (CSP) reaction with sporozoite-lnduced protective immunity in man

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7 January 2021

Letter: Sporozoite induced immunity in man against an Ethiopian strain of Plasmodium falciparum

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7 January 2021

Immunization of man against sporozite-induced falciparum malaria

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Immunization against rodent malaria with cryopreserved irradiated sporozoites of Plasmodium berghei

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

The T cell response to the malaria circumsporozoite protein: an immunological approach to vaccine development

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Infectivity of Plasmodium berghei sporozoites measured with a DNA probe

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Plasmodium berghei: the spleen in sporozoite-induced immunity to mouse malaria

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Plasmodium berghei: Accelerated clearance of sporozoites from blood as part of immune-mechanism in mice

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Studies on sporozoite-induced infections of rodent malaria. 3. The course of sporozoite-induced Plasmodium berghei in different hosts

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

An ultrastructural study of the pre-erythrocytic development of Plasmodium berghei in the tree rat, Thamnomys surdaster

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Antibodies to Sporozoites: Their Frequent Occurrence in Individuals Living in an Area of Hyperendemic Malaria

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Stage-specific antigens on the surface membrane of sporozoites of malaria parasites

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Specificity of Protective Immunity produced by X-irradiated Plasmodium berghei Sporozoites

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Molecular approaches to malaria vaccines.

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Plasmodium berghei: Relationship between protective immunity and anti-sporozoite (CSP) antibody in mice

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Congenital transfer of antibodies against malarial sporozoites detected in Gambian infants.

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Plasmodium berghei: T cell dependence of sporozoite-induced immunity in rodents

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Direct infection of hepatocytes by sporozoites of Plasmodium berghei

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Efficacy of murine malaria sporozoite vaccines: implications for human vaccine development

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Monoclonal antibodies identify the protective antigens of sporozoites of Plasmodium knowlesi

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Biosynthesis of Pb44, the protective antigen of sporozoites of Plasmodium berghei

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Rationale for development of a synthetic vaccine against plasmodium falciparum malaria

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Monoclonal antibodies to circumsporozoite proteins identify the species of malaria parasite in infected mosquitoes

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Monoclonal antibody identifies circumsporozoite protein of Plasmodium malariae and detects a common epitope on Plasmodium brasilianum sporozoites.

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Monoclonal antibodies produced against sporozoites of the human parasite Plasmodium malariae abolish infectivity of sporozoites of the simian parasite Plasmodium brasilianum

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Structure of the circumsporozoite gene of Plasmodium malariae

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Cloning and expression in E. coli of the malarial sporozoite surface antigen gene from Plasmodium knowlesi

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Identification and chemical synthesis of a tandemly repeated immunogenic region of Plasmodium knowlesi circumsporozoite protein

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

DNA Cloning of Plasmodium falciparum Circumsporozoite Gene: Amino Acid Sequence of Repetitive Epitope

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite of the Human Malaria Parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Circumsporozoite protein of Plasmodium vivax: gene cloning and characterization of the immunodominant epitope

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Sequence of the immunodominant epitope for the surface protein on sporozoites of Plasmodium vivax

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

The circumsporozoite gene of the Plasmodium cynomolgi complex

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Structure of the plasmodium knowlesi gene coding for the circumsporozoite protein

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Diversity of circumsporozoite antigen genes from two strains of the malarial parasite Plasmodium knowlesi

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Plasmodium berghei: cloning of the circumsporozoite protein gene

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Circumsporozoite protein of Plasmodium berghei: gene cloning and identification of the immunodominant epitopes

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Variation among circumsporozoite protein genes from rodent malarias

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Sticky fingers and CAAX boxes

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Biochemistry of the glycosyl-phosphatidylinositol membrane protein anchors

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Predicted conformations for the immunodominant region of the circumsporozoite protein of the human malaria parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Theoretically determined three-dimensional structure for the repeating tetrapeptide unit of the circumsporozoite coat protein of the malaria parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Synthetic peptides from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium knowlesi recognize the human hepatoma cell line HepG2-A16 in vitro

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Multiple non-repeated epitopes on the circumsporozoite protein of Plasmodium knowlesi

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Circumsporozoite gene of a Plasmodium falciparum strain from Thailand

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Strain variation in the circumsporozoite protein gene of Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Does biased gene conversion influence polymorphism in the circumsporozoite protein-encoding gene of Plasmodium vivax?

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Evolutionary profile of the circumsporozoite gene of the Plasmodium cynomolgi complex

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Malaria and the major histocompatibility complex

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Immunity to malaria and naturally acquired antibodies to the circumsporozoite protein of Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Antibodies to the repetitive epitope of Plasmodium falciparum circumsporozoite protein in a rural Tanzanian community: a longitudinal study of 132 children

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Structure of the circumsporozoite protein gene in 18 strains of Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Plasmodium falciparum: epidemiological studies on the circumsporozoite gene

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Circumsporozoite proteins of malaria parasites

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Synthetic peptide vaccine confers protection against murine malaria

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

In vivo testing of subunit vaccines against malaria sporozoites using a rodent system

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Anti-malarial Effect of Interferon Inducers at Different Stages of Development of Plasmodium berghei in the Mouse

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Interferon Inducers Protect Mice against Plasmodium berghei Malaria

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Inhibition of development of exoerythrocytic forms of malaria parasites by gamma-interferon

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P-450b and P-450e gene expression after phenobarbital

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Gamma interferon, CD8 T cells and antibodies required for immunity to malaria sporozoites

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

CD8 T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Antigen recognition. Class discrimination in the world of immunology

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Sporozoites of mammalian malaria: attachment to, interiorization and fate within macrophages

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

CD8 T lymphocytes in intracellular microbial infections

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

The pre-erythrocytic development of Plasmodium cynomolgi and Plasmodium vivax

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Oral Salmonella typhimurium vaccine expressing circumsporozoite protein protects against malaria

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Cytotoxic T cells specific for the circumsporozoite protein of plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Functional analysis of influenza-specific helper T cell clones in vivo. T cells specific for internal viral proteins provide cognate help for B cell responses to hemagglutinin

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Genetic restriction of the murine humoral response to a recombinant Plasmodium vivax circumsporozoite protein

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Genetic control of the immune response in mice to a Plasmodium falciparum sporozoite vaccine. Widespread nonresponsiveness to single malaria T epitope in highly repetitive vaccine

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Human T-cell recognition of the circumsporozoite protein of plasmodium falciparum: Immunodominant T-cell domains map to the polymorphic regions of the molecule

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Immune response of humans to the circumsporozoite protein of Plasmodium falciparum: limited T cell response to the immunodominant central repeat region.

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Construction of synthetic immunogen: use of new T-helper epitope on malaria circumsporozoite protein

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Plasmodium knowlesi sporozoite antigen: expression by infectious recombinant vaccinia virus

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Expression in yeast of a Plasmodium vivax antigen of potential use in a human malaria vaccine

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Epitopes recognized by human T lymphocytes on malaria circumsporozoite protein

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Human T cells recognize polymorphic and non-polymorphic regions of the Plasmodium falciparum circumsporozoite protein.

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Safety and immunogenicity in man of a synthetic peptide malaria vaccine against Plasmodium falciparum sporozoites

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

The Characteristics of Untreated Sporozoite-Induced and Trophozoite-Induced Infections

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Epitope-specific regulation. I. Carrier-specific induction of suppression for IgG anti-hapten antibody responses

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Effect of carrier on the immunogenic capacity of synthetic cholera vaccine

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Epitopic suppression in synthetic vaccine models: analysis of the effector mechanisms

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https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Expression of Plasmodium falciparum circumsporozoite proteins in Escherichia coli for potential use in a human malaria vaccine

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Anti-sporozoite antibodies and immunity to malaria in a rural Gambian population

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Depression of Immune Response to Moloney Leukaemia Virus by Malarial Infection

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Induction of sporozoite-specific memory cells in mice immunized with a recombinant Plasmodium vivax circumsporozoite protein

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Introduction of foreign DNA into mycobacteria using a shuttle phasmid

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Vaccinia virus expression vectors

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Proteosome-lipopeptide vaccines: enhancement of immunogenicity for malaria CS peptides

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

Conformational restriction of peptidyl immunogens with covalent replacements for the hydrogen bond

1 reference

https://api.crossref.org/works/10.1016/S0065-2776(08)60695-1

7 January 2021

10.1016/S0065-2776(08)60695-1

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