(Q38260633)

1 September 2017

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title

Translational biology of osteosarcoma (English)

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1 September 2017

Mark J Smyth

3

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David M Thomas

object named as

David M Thomas

series ordinal

4

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author name string

Maya Kansara

series ordinal

1

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1 September 2017

Michele W Teng

series ordinal

2

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1 September 2017

language of work or name

English

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publication date

16 October 2014

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1 September 2017

published in

Nature Reviews Cancer

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1 September 2017

volume

14

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1 September 2017

issue

11

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1 September 2017

page(s)

722-735

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Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma

1 September 2017

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31 March 2020

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Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice

31 March 2020

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31 March 2020

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Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma

31 March 2020

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31 March 2020

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Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas

31 March 2020

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

31 March 2020

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Histone Deacetylase Inhibitor Activates the WAF1/Cip1 Gene Promoter through the Sp1 Sites

31 March 2020

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Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP.

31 March 2020

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Separate and combined effects of DNMT and HDAC inhibitors in treating human multi-drug resistant osteosarcoma HosDXR150 cell line

31 March 2020

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Enhancement of radiosensitivity by 5-Aza-CdR through activation of G2/M checkpoint response and apoptosis in osteosarcoma cells

31 March 2020

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Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions.

31 March 2020

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RANK is essential for osteoclast and lymph node development

31 March 2020

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RANKL expression is related to treatment outcome of patients with localized, high‐grade osteosarcoma

31 March 2020

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Formulated siRNAs targeting Rankl prevent osteolysis and enhance chemotherapeutic response in osteosarcoma models

31 March 2020

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Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice

31 March 2020

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Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma

31 March 2020

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Pleiotropic effects of bisphosphonates on osteosarcoma.

31 March 2020

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153Samarium-EDTMP administration followed by hematopoietic stem cell support for bone metastases in osteosarcoma patients

31 March 2020

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Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma.

31 March 2020

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Targeting hedgehog-GLI-2 pathway in osteosarcoma.

31 March 2020

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Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma

31 March 2020

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Notch Signaling is Associated with ALDH Activity and an Aggressive Metastatic Phenotype in Murine Osteosarcoma Cells

31 March 2020

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Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling

31 March 2020

1 reference

High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A.

31 March 2020

1 reference

Wnt pathway in osteosarcoma, from oncogenic to therapeutic

31 March 2020

1 reference

Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma.

31 March 2020

1 reference

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

31 March 2020

1 reference

Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma

31 March 2020

1 reference

Prognostic significance of VEGF expression in osteosarcoma: a meta-analysis

31 March 2020

1 reference

A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group study

31 March 2020

1 reference

Expression of platelet-derived growth factor-AA is associated with tumor progression in osteosarcoma

31 March 2020

1 reference

Dynamic analysis of lung metastasis by mouse osteosarcoma LM8: VEGF is a candidate for anti-metastasis therapy

31 March 2020

1 reference

Effect of c-erbB2 overexpression on prognosis in osteosarcoma: evidence from eight studies.

31 March 2020

1 reference

Expression of HER2/erbB-2 correlates with survival in osteosarcoma

31 March 2020

1 reference

Clinicopathologic analysis of HER-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma

31 March 2020

1 reference

Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group

31 March 2020

1 reference

Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma

31 March 2020

1 reference

IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma

31 March 2020

1 reference

Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: a report from the Children's Oncology Group

31 March 2020

1 reference

c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells

31 March 2020

1 reference

The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model

31 March 2020

1 reference

Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo

31 March 2020

1 reference

Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells

31 March 2020

1 reference

Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas

31 March 2020

1 reference

Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy

31 March 2020

1 reference

The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models.

31 March 2020

1 reference

Physiological and oncogenic Aurora-A pathway

31 March 2020

1 reference

Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

31 March 2020

1 reference

Inhibition of Aurora-B suppresses osteosarcoma cell migration and invasion

31 March 2020

1 reference

Sipuleucel-T immunotherapy for castration-resistant prostate cancer

31 March 2020

1 reference

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

31 March 2020

1 reference

Cancer despite immunosurveillance: immunoselection and immunosubversion

31 March 2020

1 reference

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

31 March 2020

1 reference

RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

31 March 2020

1 reference

Requirement for NF-κB in osteoclast and B-cell development

31 March 2020

1 reference

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

31 March 2020

1 reference

31 March 2020

1 reference

Osteoimmunology: interactions of the bone and immune system

31 March 2020

1 reference

II. Contribution to the Knowledge of Sarcoma

31 March 2020

1 reference

Phase I clinical trial of mixed bacterial vaccine (Coley's toxins) in patients with NY-ESO-1 expressing cancers: immunological effects and clinical activity

31 March 2020

1 reference

Post operative infection and increased survival in osteosarcoma patients: are they associated?

31 March 2020

1 reference

Immunological aspects of cancer chemotherapy

31 March 2020

1 reference

Prognostic significance of early lymphocyte recovery in pediatric osteosarcoma.

31 March 2020

1 reference

Phase II study of liposomal muramyl tripeptide in osteosarcoma: the cytokine cascade and monocyte activation following administration

31 March 2020

1 reference

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

31 March 2020

1 reference

Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide

31 March 2020

1 reference

Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology Group

31 March 2020

1 reference

Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group

31 March 2020

1 reference

Mifamurtide for high-grade, resectable, nonmetastatic osteosarcoma following surgical resection: a cost-effectiveness analysis

31 March 2020

1 reference

The prognostic significance of immune changes in patients with renal cell carcinoma treated with interferon alfa-2b

31 March 2020

1 reference

Interferons and bone. A comparison of the effects of interferon-alpha and interferon-gamma in cultures of human bone-derived cells and an osteosarcoma cell line

31 March 2020

1 reference

Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis

31 March 2020

1 reference

Antitumor effect of human leukocyte interferon on human osteosarcoma transplanted into nude mice

31 March 2020

1 reference

Adjuvant interferon treatment in human osteosarcoma

31 March 2020

1 reference

Interferons and osteosarcoma

31 March 2020

1 reference

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

31 March 2020

1 reference

Immunogenic cell death in cancer therapy

31 March 2020

1 reference

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance

31 March 2020

1 reference

Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacy

31 March 2020

1 reference

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma

31 March 2020

1 reference

Association between CTLA-4 genetic polymorphisms and susceptibility to osteosarcoma in Chinese Han population

31 March 2020

1 reference

Cytotoxic T-lymphocyte antigen-4 polymorphisms and susceptibility to osteosarcoma.

31 March 2020

1 reference

Enhancement of antitumor immunity by combining anti-cytotoxic T lymphocyte antigen-4 antibodies and cryotreated tumor lysate-pulsed dendritic cells in murine osteosarcoma

31 March 2020

1 reference

Targeting PD-1/PD-L1 interactions for cancer immunotherapy

31 March 2020

1 reference

Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma

31 March 2020

1 reference

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

31 March 2020

1 reference

New concepts on the immune modulation mediated by mesenchymal stem cells

31 March 2020

1 reference

Expression of a newly defined tumor-rejection antigen SART3 in musculoskeletal tumors and induction of HLA class I-restricted cytotoxic T lymphocytes by SART3-derived peptides

31 March 2020

1 reference

Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma

31 March 2020

1 reference

Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR.

31 March 2020

1 reference

Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma

31 March 2020

1 reference

Anti-GD2 antibody therapy for GD2-expressing tumors

31 March 2020

1 reference

Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.

31 March 2020

1 reference

Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy

31 March 2020

1 reference

Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment

31 March 2020

1 reference

Children's Oncology Group's 2013 blueprint for research: bone tumors

31 March 2020

1 reference

The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate

31 March 2020

1 reference

Different expression of CD146 in human normal and osteosarcoma cell lines

31 March 2020

1 reference

Dendritic cell immunotherapy is effective for lung metastasis from murine osteosarcoma

31 March 2020

1 reference

Killer dendritic cells link innate and adaptive immunity against established osteosarcoma in rats

31 March 2020

1 reference

Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma

31 March 2020

1 reference

Feasibility of high-dose interleukin-2 in heavily pretreated pediatric cancer patients

31 March 2020

1 reference

Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity

31 March 2020

1 reference

The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases

31 March 2020

1 reference

Fas-negative osteosarcoma tumor cells are selected during metastasis to the lungs: the role of the Fas pathway in the metastatic process of osteosarcoma

31 March 2020

1 reference

Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma: effects on disease-free survival and immunomodulation. a report from the Children's Oncology Group

31 March 2020

1 reference

Molecularly targeted cancer therapy: some lessons from the past decade

31 March 2020

1 reference

Realizing the promise of cancer predisposition genes

31 March 2020

1 reference

Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival

31 March 2020

1 reference

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

31 March 2020

1 reference

Getting personal with neoantigen-based therapeutic cancer vaccines

31 March 2020

1 reference

Cancer in children and adolescents in Europe: developments over 20 years and future challenges.

31 March 2020

1 reference

Stature of young people with malignant bone tumors

31 March 2020

1 reference

Radiation induced extraskeletal osteosarcoma

31 March 2020

1 reference

Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood

31 March 2020

1 reference

Paget disease of bone: diagnosis and drug therapy

31 March 2020

1 reference

Bone sarcomas in Paget disease: a study of 85 patients

31 March 2020

1 reference

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone

31 March 2020

1 reference

Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma

31 March 2020

1 reference

Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition

31 March 2020

1 reference

RecQ Helicases: Conserved Guardians of Genomic Integrity.

31 March 2020

1 reference

Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome.

31 March 2020

1 reference

Clinical manifestations in a cohort of 41 Rothmund-Thomson syndrome patients

31 March 2020

1 reference

31 March 2020

1 reference

Spectrum and risk of neoplasia in Werner syndrome: a systematic review

31 March 2020

1 reference

Bloom's syndrome. XX. The first 100 cancers

31 March 2020

1 reference

Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases

31 March 2020

1 reference

p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate

31 March 2020

1 reference

Novel physiological RECQL4 alternative transcript disclosed by molecular characterisation of Rothmund-Thomson Syndrome sibs with mild phenotype.

31 March 2020

1 reference

Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma

31 March 2020

1 reference

Aberrant methylation of p14ARF gene correlates with poor survival in osteosarcoma.

31 March 2020

1 reference

Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma

31 March 2020

1 reference

Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma

31 March 2020

1 reference

Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis

31 March 2020

1 reference

Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes

31 March 2020

1 reference

LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization

31 March 2020

1 reference

Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma

31 March 2020

1 reference

Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors

31 March 2020

1 reference

Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis

31 March 2020

1 reference

Epigenetic regulation of the pro-apoptosis gene TSSC3 in human osteosarcoma cells

31 March 2020

1 reference

Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells

31 March 2020

1 reference

Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma

31 March 2020

1 reference

CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

31 March 2020

1 reference

Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma

31 March 2020

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Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas

31 March 2020

1 reference

Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma

31 March 2020

1 reference

Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma

31 March 2020

1 reference

Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma

31 March 2020

1 reference

Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma

31 March 2020

1 reference

Cyclin E1 is amplified and overexpressed in osteosarcoma.

31 March 2020

1 reference

COPS3 amplification and clinical outcome in osteosarcoma

31 March 2020

1 reference

Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma

31 March 2020

1 reference

Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site

31 March 2020

1 reference

Mifamurtide in metastatic and recurrent osteosarcoma: a patient access study with pharmacokinetic, pharmacodynamic, and safety assessments

31 March 2020

1 reference

Long-Term Adjuvant Interferon Treatment of Human Osteosarcoma: A pilot study

31 March 2020

1 reference

Intranasal therapy with an adenoviral vector containing the murine interleukin-12 gene eradicates osteosarcoma lung metastases

31 March 2020

1 reference

12 December 2020

Immune escape of tumors: apoptosis resistance and tumor counterattack.

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12 December 2020

Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide

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12 December 2020

Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms

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12 December 2020

Inactivation of the RASSF1A in osteosarcoma

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12 December 2020

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good R

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12 December 2020

Several mutant p53 proteins detected in cancer-prone families with Li-Fraumeni syndrome exhibit transdominant effects on the biochemical properties of the wild-type p53.

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12 December 2020

Expression of the SART1 tumor-rejection antigen in human osteosarcomas

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12 December 2020

Aberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcoma

1 reference

12 December 2020

Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program.

1 reference

12 December 2020

Intrinsic and extrinsic manipulation of B7/CTLA-4 interaction for induction of anti-tumor immunity against osteosarcoma cells.

1 reference

12 December 2020

Inhibitory effect and significance of rapamycin on the mammalian target of rapamycin signaling pathway in osteosarcoma stem cells and osteosarcoma cells

1 reference

12 December 2020

Effect of human granulocyte macrophage-colony stimulating factor on differentiation and apoptosis of the human osteosarcoma cell line SaOS-2.

1 reference

12 December 2020

Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary.

1 reference

12 December 2020

Genome-wide analyses on high-grade osteosarcoma: making sense of a genomically most unstable tumor.

1 reference

12 December 2020

Potentiating effect of muramyl dipeptide and its lipophilic analog encapsulated in liposomes on tumor cell killing by human monocytes

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12 December 2020

Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells.

1 reference

12 December 2020

Ring chromosomes in parosteal osteosarcoma contain sequences from 12q13-15: a combined cytogenetic and comparative genomic hybridization study

1 reference

12 December 2020

Osteosarcoma. Results of treatment employing adjuvant immunotherapy

1 reference

12 December 2020

Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.

1 reference

12 December 2020

Suppression of tumour metastasis in a murine osteosarcoma model with anti-CD25 monoclonal antibody treatment

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12 December 2020

The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus).

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12 December 2020

Identifiers

DOI

10.1038/NRC3838

1 reference

Dimensions Publication ID

1 September 2017

1032448549

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