(Q37940573)

25 August 2017

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title

Drug resistance in human African trypanosomiasis (English)

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25 August 2017

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African trypanosomiasis

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1

Michael P Barrett

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Isabel Vincent

object named as

Isabel M Vincent

2

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Enock Matovu

object named as

Enock Matovu

5

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author name string

Michael P Barrett

1

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25 August 2017

Richard J S Burchmore

3

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25 August 2017

Anne J N Kazibwe

4

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25 August 2017

publication date

1 September 2011

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25 August 2017

number of pages

11

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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25 August 2017

volume

6

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25 August 2017

issue

9

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25 August 2017

page(s)

1037-1047

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Human African trypanosomiasis

25 August 2017

cites work

1 reference

Development of novel drugs for human African trypanosomiasis

21 January 2018

1 reference

A spectrum of disease in human African trypanosomiasis: the host and parasite genetics of virulence

21 January 2018

1 reference

Controlling sleeping sickness - a review

21 January 2018

1 reference

The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward

21 January 2018

1 reference

Murine Models for Trypanosoma brucei gambiense disease progression--from silent to chronic infections and early brain tropism

21 January 2018

1 reference

Antimalaria drug resistance: the mono-combi-counterfeit triangle

21 January 2018

1 reference

Development and validation of an improved HPLC method for the control of potentially counterfeit isometamidium products

21 January 2018

1 reference

Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

21 January 2018

1 reference

Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein

21 January 2018

1 reference

Distribution of suramin, an antitrypanosomal drug, across the blood-brain and blood-cerebrospinal fluid interfaces in wild-type and P-glycoprotein transporter-deficient mice

21 January 2018

1 reference

Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with pentamidine

21 January 2018

1 reference

Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the Congo

21 January 2018

1 reference

The phenomenon of treatment failures in Human African Trypanosomiasis

21 January 2018

1 reference

Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy

21 January 2018

1 reference

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal

21 January 2018

1 reference

Genotypic and phenotypic characterization of Trypanosoma brucei gambiense isolates from Ibba, South Sudan, an area of high melarsoprol treatment failure rate

21 January 2018

1 reference

Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo

21 January 2018

1 reference

Arsenical-resistant trypanosomes lack an unusual adenosine transporter

21 January 2018

1 reference

A nucleoside transporter from Trypanosoma brucei involved in drug resistance.

21 January 2018

1 reference

Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei

21 January 2018

1 reference

Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes

21 January 2018

1 reference

Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance

21 January 2018

1 reference

The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes

21 January 2018

1 reference

Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance

21 January 2018

1 reference

Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns

21 January 2018

1 reference

Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes

21 January 2018

1 reference

Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test

21 January 2018

1 reference

McArthur revisited: fluorescence microscopes for field diagnostics

21 January 2018

1 reference

Two novel nucleobase/pentamidine transporters from Trypanosoma brucei

21 January 2018

1 reference

Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine

21 January 2018

1 reference

RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis

21 January 2018

1 reference

Uptake of alpha-difluoromethylornithine by Trypanosoma brucei brucei

21 January 2018

1 reference

Biochemical changes associated with alpha-difluoromethylornithine uptake and resistance in Trypanosoma brucei

21 January 2018

1 reference

A Trypanosoma brucei mutant resistant to alpha-difluoromethylornithine.

21 January 2018

1 reference

A molecular mechanism for eflornithine resistance in African trypanosomes

21 January 2018

1 reference

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters.

21 January 2018

1 reference

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

21 January 2018

1 reference

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

21 January 2018

1 reference

Trypanocidal drugs: mechanisms, resistance and new targets

21 January 2018

1 reference

The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-cerebrospinal fluid barriers

21 January 2018

1 reference

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

21 January 2018

1 reference

Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.

21 January 2018

1 reference

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis

21 January 2018

1 reference

Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness

21 January 2018

1 reference

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

21 January 2018

1 reference

Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes

21 January 2018

1 reference

Combined contribution of TbAT1 and TbMRPA to drug resistance in Trypanosoma brucei

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FMB.11.88

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25 August 2017

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