(Q37112916)

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Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97

scientific article published on January 2007

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24 December 2019

Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97 (English)

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24 December 2019

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24 December 2019

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Sarah C R Lummis

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24 December 2019

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Claire L Padgett

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24 December 2019

Ariele P Hanek

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24 December 2019

Dennis A Dougherty

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24 December 2019

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1 January 2007

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24 December 2019

Journal of Neuroscience

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24 December 2019

27

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24 December 2019

4

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24 December 2019

886-892

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24 December 2019

On the accuracy of homology modeling and sequence alignment methods applied to membrane proteins

1 reference

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GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures

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Invariant aspartic Acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding

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Organic fluorine: odd man out.

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Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine

1 reference

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Anxiety over GABA(A) receptor structure relieved by AChBP.

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FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

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14 September 2017

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

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14 September 2017

From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor

1 reference

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14 September 2017

Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists.

1 reference

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14 September 2017

Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide

1 reference

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14 September 2017

Comparative protein modelling by satisfaction of spatial restraints

1 reference

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14 September 2017

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

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14 September 2017

Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

1 reference

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14 September 2017

An arginine involved in GABA binding and unbinding but not gating of the GABA(A) receptor.

1 reference

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29 September 2017

Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor

1 reference

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27 June 2018

GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions

1 reference

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27 June 2018

Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis.

1 reference

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27 June 2018

In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system.

1 reference

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27 June 2018

GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital

1 reference

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27 June 2018

Subunit stoichiometry of a mammalian K channel determined by construction of multimeric cDNAs.

1 reference

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27 June 2018

A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor

1 reference

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3 September 2018

Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor

1 reference

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Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis.

1 reference

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3 September 2018

Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?

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3 September 2018

Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions

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Mapping the agonist binding site of the GABAA receptor: evidence for a beta-strand.

1 reference

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Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit.

1 reference

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Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

1 reference

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Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells

1 reference

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3 September 2018

Identifiers

10.1523/JNEUROSCI.4791-06.2007

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251430 AND SRC:MED&resulttype=core&format=json

24 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251430 AND SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251430 AND SRC:MED&resulttype=core&format=json

24 December 2019

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