(Q36867191)

16 August 2017

title

Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D. (English)

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16 August 2017

Kick EK

1

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16 August 2017

Roe DC

2

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16 August 2017

Skillman AG

3

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16 August 2017

Liu G

4

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16 August 2017

Ewing TJ

5

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16 August 2017

Sun Y

6

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16 August 2017

Kuntz ID

7

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16 August 2017

Ellman JA

8

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16 August 2017

publication date

1 April 1997

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16 August 2017

published in

Chemistry and Biology

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16 August 2017

volume

4

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16 August 2017

issue

4

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16 August 2017

page(s)

297-307

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Structure-based strategies for drug design and discovery

16 August 2017

cites work

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Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries

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Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors

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Cathepsin D and breast cancer

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Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease.

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The selectivity of statine-based inhibitors against various human aspartic proteinases

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Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin

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Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries

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Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

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7 January 2021

Automated docking with grid-based energy evaluation

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7 January 2021

Tight-binding inhibitors-II. Non-steady state nature of inhibition of milk xanthine oxidase by allopurinol and alloxanthine and of human erythrocytic adenosine deaminase by coformycin

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7 January 2021

10.1016/S1074-5521(97)90073-9

Identifiers

DOI

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16 August 2017

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