(Q36404147)

14 August 2017

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title

Building mammalian signalling pathways with RNAi screens (English)

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14 August 2017

2

David M Sabatini

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14 August 2017

Jason Moffat

1

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14 August 2017

publication date

1 March 2006

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Nature Reviews Molecular Cell Biology

14 August 2017

published in

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14 August 2017

volume

7

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14 August 2017

issue

3

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14 August 2017

page(s)

177-187

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New tools for functional mammalian cancer genetics

14 August 2017

cites work

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Unlocking the potential of the human genome with RNA interference

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

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Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

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Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

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Genome-wide RNAi analysis of growth and viability in Drosophila cells

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How cells respond to interferons

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Gene silencing using micro-RNA designed hairpins

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A system for stable expression of short interfering RNAs in mammalian cells

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Lentiviral-mediated RNA interference

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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Lentivirus-delivered stable gene silencing by RNAi in primary cells

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Transcription and processing of human microRNA precursors

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Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

21 January 2018

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Second-generation shRNA libraries covering the mouse and human genomes

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Interactions between double-stranded RNA regulators and the protein kinase DAI

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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A resource for large-scale RNA-interference-based screens in mammals.

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Adenoviral vectors expressing siRNAs for discovery and validation of gene function

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Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

21 January 2018

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Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis

21 January 2018

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High-throughput RNAi screening in vitro: from cell lines to primary cells.

21 January 2018

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

21 January 2018

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MicroRNA genes are transcribed by RNA polymerase II

21 January 2018

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The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

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Processing of primary microRNAs by the Microprocessor complex

21 January 2018

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The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis

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The Drosha-DGCR8 complex in primary microRNA processing

21 January 2018

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The Microprocessor complex mediates the genesis of microRNAs

21 January 2018

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

21 January 2018

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Nuclear export of microRNA precursors

21 January 2018

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Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

21 January 2018

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A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

21 January 2018

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Stable suppression of gene expression by RNAi in mammalian cells

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Restriction enzyme-generated siRNA (REGS) vectors and libraries

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Enzymatic production of RNAi libraries from cDNAs.

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An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

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A genetic screen for candidate tumor suppressors identifies REST

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A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

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Cell microarrays and RNA interference chip away at gene function

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Genome-wide survey of protein kinases required for cell cycle progression.

21 January 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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A gene network for navigating the literature

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Global mapping of the yeast genetic interaction network

21 January 2018

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Functional genomic analysis of the Wnt-wingless signaling pathway

21 January 2018

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Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity

21 January 2018

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Growing roles for the mTOR pathway

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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Electroporation and RNA interference in the rodent retina in vivo and in vitro

21 January 2018

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Local gene knockdown in the brain using viral-mediated RNA interference.

21 January 2018

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siRNA-mediated gene silencing in vitro and in vivo.

21 January 2018

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Sequence-specific gene silencing in murine muscle induced by electroporation-mediated transfer of short interfering RNA.

21 January 2018

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Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype

21 January 2018

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Cre-lox-regulated conditional RNA interference from transgenes

21 January 2018

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A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

21 January 2018

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

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Synthetic shRNAs as potent RNAi triggers

21 January 2018

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Systematic genome-wide screens of gene function

21 January 2018

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Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

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Noise amidst the silence: off-target effects of siRNAs?

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NRM1860

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14 August 2017

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