(Q35091120)

6 August 2017

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title

NF-kappaB in cancer: a marked target (English)

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6 August 2017

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2

Michael Karin

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6 August 2017

Anning Lin

1

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6 August 2017

publication date

1 April 2003

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Seminars in Cancer Biology

6 August 2017

published in

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6 August 2017

volume

13

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6 August 2017

issue

2

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6 August 2017

page(s)

107-114

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Molecular themes in oncogenesis

6 August 2017

cites work

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Cooperation between oncogenes

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Oncogenes and signal transduction

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Apoptosis in cancer therapy: crossing the threshold

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Proliferation, cell cycle and apoptosis in cancer

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Missing pieces in the NF-kappaB puzzle

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

NF-kappaB in cancer: from innocent bystander to major culprit

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

NF-kappaB at the crossroads of life and death

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

RelB cellular regulation and transcriptional activity are regulated by p100.

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Characterization of XIAP-deficient mice

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Inhibition of JNK activation through NF-kappaB target genes

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Inhibition of death receptor signals by cellular FLIP

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Casper is a FADD- and caspase-related inducer of apoptosis

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Signal transduction by tumor necrosis factor and its relatives

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4 lymphocytes

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https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

TRAF2 Is Essential for JNK but Not NF-κB Activation and Regulates Lymphocyte Proliferation and Survival

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Activation of the JNK signaling pathway: breaking the brake on apoptosis

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Translocation of TRAF proteins regulates apoptotic threshold of cells

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Modulation of cell death by Bcl-x L through caspase interaction

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease.

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Inhibition of NF-kappa B by sodium salicylate and aspirin

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

1 reference

https://api.crossref.org/works/10.1016/S1044-579X(02)00128-1

7 January 2021

10.1016/S1044-579X(02)00128-1

Identifiers

DOI

1 reference

6 August 2017

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