(Q35045715)

6 August 2017

title

MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity (English)

1 reference

6 August 2017

Wu Yang

1

1 reference

6 August 2017

John Guastella

2

1 reference

6 August 2017

Jin-Cheng Huang

3

1 reference

6 August 2017

Yan Wang

4

1 reference

6 August 2017

Li Zhang

5

1 reference

6 August 2017

Dong Xue

6

1 reference

6 August 2017

Minhtam Tran

7

1 reference

6 August 2017

Richard Woodward

8

1 reference

6 August 2017

Shailaja Kasibhatla

9

1 reference

6 August 2017

Ben Tseng

10

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6 August 2017

John Drewe

11

1 reference

6 August 2017

Sui Xiong Cai

12

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6 August 2017

language of work or name

English

0 references

publication date

26 August 2003

1 reference

British Journal of Pharmacology

6 August 2017

published in

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6 August 2017

volume

140

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6 August 2017

issue

2

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6 August 2017

page(s)

402-412

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Apoptosis-based therapies

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

How cells die: apoptosis pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

In vivo myocardial infarct size reduction by a caspase inhibitor administered after the onset of ischemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Neuroprotection by the inhibition of apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock.

8 July 2018

1 reference

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Caspase activation: the induced-proximity model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Apoptosis in myocardial ischemia-reperfusion.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Caspases as treatment targets in stroke and neurodegenerative diseases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

The domains of death: evolution of the apoptosis machinery

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Neuroprotection by a caspase inhibitor in acute bacterial meningitis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

8 July 2018

Caspases: Enemies Within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Caspases: key mediators of apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Apoptosis in the pathogenesis and treatment of disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

The behavior and significance of slow-binding enzyme inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

New Fluorogenic Substrates for α-Thrombin, Factor Xa, Kallikreins, and Urokinase1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Interleukin-1 beta converting enzyme.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

(p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitor of serine proteases

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574042

Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization

25 October 2018

1 reference

12 December 2020

A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis

1 reference

12 December 2020

A specific inhibitor of apoptosis decreases tissue injury after intestinal ischemia-reperfusion in mice

1 reference

12 December 2020

Apoptosis: basic mechanisms and implications for cardiovascular disease

1 reference

12 December 2020

New fluorogenic substrates for renin

1 reference

12 December 2020

Attenuation of Ischemia/Reperfusion Injury in Rats by a Caspase Inhibitor

1 reference

12 December 2020

Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group

1 reference

12 December 2020

Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

1 reference

12 December 2020

Essential roles of the Fas ligand in the development of hepatitis

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0705450

1 reference

6 August 2017

1 reference

6 August 2017

1 reference