(Q34987286)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

14 December 2019

review article

1 reference

title

Making and breaking tolerance (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

14 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

14 December 2019

author name string

Anthony L DeFranco

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

14 December 2019

publication date

1 December 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

Current Opinion in Immunology

14 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

14 December 2019

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

14 December 2019

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

14 December 2019

page(s)

744-759

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

Cross-presentation, dendritic cells, tolerance and immunity

14 December 2019

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CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

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Stimulation of CD25( )CD4( ) regulatory T cells through GITR breaks immunological self-tolerance

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CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells

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7 January 2021

Dendritic and natural killer cells cooperate in the control/switch of innate immunity

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7 January 2021

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity

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Effectiveness of Lipid and Lipidophilic Substances as Adjuvants

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7 January 2021

Conversion of immunological paralysis to immunity by endotoxin

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Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).

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Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

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7 January 2021

Infection breaks T-cell tolerance.

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7 January 2021

The danger model: a renewed sense of self

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7 January 2021

Decoding the patterns of self and nonself by the innate immune system

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7 January 2021

Dendritic cell maturation is required for the cross-tolerization of CD8 T cells

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7 January 2021

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo

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7 January 2021

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

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7 January 2021

Conversion of tumor-specific CD4 T-cell tolerance to T-cell priming through in vivo ligation of CD40

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7 January 2021

Role of antigen-presenting cells in mediating tolerance and autoimmunity

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7 January 2021

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance.

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Innate immune recognition

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Primitive Toll signalling: bugs, flies, worms and man.

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7 January 2021

Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?

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7 January 2021

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

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7 January 2021

Toll-like receptors: critical proteins linking innate and acquired immunity

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7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

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7 January 2021

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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7 January 2021

TIRAP: an adapter molecule in the Toll signaling pathway

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7 January 2021

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

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7 January 2021

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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7 January 2021

IRAK-M is a negative regulator of Toll-like receptor signaling

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7 January 2021

TREM-1 amplifies inflammation and is a crucial mediator of septic shock

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7 January 2021

Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17

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7 January 2021

Lipopolysaccharide interferes with the induction of peripheral T cell death.

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7 January 2021

Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8 T cells to cause immunopathology

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7 January 2021

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

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7 January 2021

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

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7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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7 January 2021

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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7 January 2021

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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7 January 2021

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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7 January 2021

A Toll-like receptor recognizes bacterial DNA

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7 January 2021

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

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7 January 2021

Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells

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7 January 2021

Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3'-OH kinase pathway.

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7 January 2021

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

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7 January 2021

Roles of heat-shock proteins in innate and adaptive immunity

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7 January 2021

Natural adjuvants: endogenous activators of dendritic cells

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7 January 2021

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway

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7 January 2021

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

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7 January 2021

Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

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7 January 2021

Heat shock proteins generate beta-chemokines which function as innate adjuvants enhancing adaptive immunity

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7 January 2021

Primary tumor tissue lysates are enriched in heat shock proteins and induce the maturation of human dendritic cells.

1 reference

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7 January 2021

Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells.

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7 January 2021

The role of heat shock protein (hsp70) in dendritic cell maturation: hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors

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7 January 2021

Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells

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7 January 2021

Stress management - heat shock protein-70 and the regulation of apoptosis

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7 January 2021

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

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7 January 2021

Heat-shock proteins as activators of the innate immune system

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7 January 2021

CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin

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7 January 2021

Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides

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7 January 2021

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

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7 January 2021

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

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7 January 2021

Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells

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7 January 2021

Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells

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7 January 2021

HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway

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7 January 2021

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

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7 January 2021

Heat shock proteins 70 and 60 share common receptors which are expressed on human monocyte-derived but not epidermal dendritic cells

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7 January 2021

The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins

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7 January 2021

CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines

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7 January 2021

An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells

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7 January 2021

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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7 January 2021

Oligosaccharides of hyaluronan are potent activators of dendritic cells

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7 January 2021

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

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7 January 2021

Phenotypic and Functional Maturation of Dendritic Cells Mediated by Heparan Sulfate

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7 January 2021

The extra domain A of fibronectin activates Toll-like receptor 4.

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7 January 2021

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

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7 January 2021

The CD8 dendritic cell subset selectively endocytoses dying cells in culture and in vivo

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7 January 2021

CD8( ) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.

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7 January 2021

Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo

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7 January 2021

Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells

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7 January 2021

In situ beta cell death promotes priming of diabetogenic CD8 T lymphocytes

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7 January 2021

Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance

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7 January 2021

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires

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7 January 2021

Receptor selection in B and T lymphocytes

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7 January 2021

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

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7 January 2021

Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.

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7 January 2021

Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive.

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7 January 2021

Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells

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7 January 2021

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4 T cells

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7 January 2021

Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

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7 January 2021

Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.

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7 January 2021

Chronic graft-versus-host in Ig knockin transgenic mice abrogates B cell tolerance in anti-double-stranded DNA B cells

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7 January 2021

The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells

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7 January 2021

Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded

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7 January 2021

Functional consequences of the developmental arrest and follicular exclusion of anti-double-stranded DNA B cells

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7 January 2021

Persistence of partially functional double-stranded (ds) DNA binding B cells in mice transgenic for the IgM heavy chain of an anti-dsDNA antibody

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7 January 2021

Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease

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7 January 2021

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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7 January 2021

From T to B and back again: positive feedback in systemic autoimmune disease

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7 January 2021

CpG motifs in bacterial DNA and their immune effects

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7 January 2021

Delineating the genetic basis of systemic lupus erythematosus

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https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes

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https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

C3d of complement as a molecular adjuvant: bridging innate and acquired immunity

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

A critical role for complement in maintenance of self-tolerance

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Positive and negative roles of the tyrosine kinase Lyn in B cell function

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP)

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Partially distinct molecular mechanisms mediate inhibitory FcgammaRIIB signaling in resting and activated B cells

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP?

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Increased severity of experimental allergic encephalomyelitis in lyn-/- mice in the absence of elevated proinflammatory cytokine response in the central nervous system.

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded DNA Ig transgenic mice

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7 January 2021

Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis

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7 January 2021

Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice

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7 January 2021

Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity

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7 January 2021

CD5-negative regulation of B cell receptor signaling pathways originates from tyrosine residue Y429 outside an immunoreceptor tyrosine-based inhibitory motif

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https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

CD5 maintains tolerance in anergic B cells

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Quantitative genetic variation in CD19 expression correlates with autoimmunity

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Lymphocyte signaling: Cbl sets the threshold for autoimmunity

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Cbl-b regulates the CD28 dependence of T-cell activation.

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen.

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators.

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

T-cell signalling and autoimmunity: molecular mechanisms of disease

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Impaired Fas response and autoimmunity in Pten /- mice

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

1 reference

https://api.crossref.org/works/10.1016/S0952-7915(02)00406-5

7 January 2021

10.1016/S0952-7915(02)00406-5

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12413525 AND SRC:MED&resulttype=core&format=json

14 December 2019

1 reference