(Q34646667)

3 August 2017

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title

The genetics of the E2F family of transcription factors: shared functions and unique roles (English)

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3 August 2017

James DeGregori

1

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3 August 2017

language of work or name

English

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publication date

1 June 2002

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Biochimica et Biophysica Acta

3 August 2017

published in

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3 August 2017

volume

1602

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3 August 2017

issue

2

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3 August 2017

page(s)

131-150

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Identification of a cellular transcription factor involved in E1A trans-activation

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The E2F transcription factor is a cellular target for the RB protein

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F target genes and cell-cycle checkpoint control

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Identification of a growth suppression domain within the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The Rb/E2F pathway and cancer

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The regulation of E2F by pRB-family proteins

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-6, a member of the E2F family that can behave as a transcriptional repressor

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

An E2F-like repressor of transcription

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-5, a new E2F family member that interacts with p130 in vivo

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The subcellular localization of E2F-4 is cell-cycle dependent

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Identification of Positively and Negatively Acting Elements Regulating Expression of the E2F2 Gene in Response to Cell Growth Signals

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Complex transcriptional regulatory mechanisms control expression of the E2F3 locus

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Regulation of E2F1 activity by acetylation

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F Family Members Are Differentially Regulated by Reversible Acetylation

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Specific regulation of E2F family members by cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Regulation of E2F: a family of transcription factors involved in proliferation control

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F is required to prevent inappropriate S-phase entry of mammalian cells

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Distinct roles for E2F proteins in cell growth control and apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Multiple members of the E2F transcription factor family are the products of oncogenes

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Oncogenic capacity of the E2F1 gene

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The E2F-family proteins induce distinct cell cycle regulatory factors in p16-arrested, U343 astrocytoma cells

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Blocking the transcription factor E2F/DP by dominant-negative mutants in a normal breast epithelial cell line efficiently inhibits apoptosis and induces tumor growth in SCID mice

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Cell cycle regulation of E2F site occupation in vivo.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Functional antagonism between E2F family members

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Retinoblastoma protein recruits histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Retinoblastoma protein switches the E2F site from positive to negative element

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Rb Interacts with Histone Deacetylase to Repress Transcription

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Functional interplay between p53 and E2F through co-activator p300.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

A rough guide to a smooth brain

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Linking the Rb and polycomb pathways

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Mammalian chromodomain proteins: their role in genome organisation and expression

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Rb targets histone H3 methylation and HP1 to promoters

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Active repression and E2F inhibition by pRB are biochemically distinguishable

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Rb-mediated chromatin structure regulation and transcriptional repression

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The Rb/E2F pathway: expanding roles and emerging paradigms

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Target gene specificity of E2F and pocket protein family members in living cells

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Cell cycle-dependent recruitment of HDAC-1 correlates with deacetylation of histone H4 on an Rb-E2F target promoter

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The transcription factor E2F is required for S phase during Drosophila embryogenesis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Mutations in Drosophila DP and E2F distinguish G1–S progression from an associated transcriptional program

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Pocket protein-independent repression of urokinase-type plasminogen activator and plasminogen activator inhibitor 1 gene expression by E2F1

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The transcriptional program in the response of human fibroblasts to serum

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Transcriptional regulation and function during the human cell cycle

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Rapid analysis of gene expression (RAGE) facilitates universal expression profiling

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

DNA replication control through interaction of E2F-RB and the origin recognition complex

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Nuclear organization of DNA replication in primary mammalian cells.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Mutation of E2F2 in Mice Causes Enhanced T Lymphocyte Proliferation, Leading to the Development of Autoimmunity

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F4 is essential for normal erythrocyte maturation and neonatal viability

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Loss of E2F4 activity leads to abnormal development of multiple cellular lineages

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Immunology: improving on nature in the twenty-first century

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Human ARF binds E2F1 and inhibits its transcriptional activity.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

p19ARF targets certain E2F species for degradation.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Role for the p53 homologue p73 in E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Role of the p53-homologue p73 in E2F1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The E2F1-3 transcription factors are essential for cellular proliferation.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Requirements for cell cycle arrest by p16INK4a

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The retinoblastoma protein is linked to the activation of Ras.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1( /-)mice

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Requirement for a functional Rb-1 gene in murine development

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Effects of an Rb mutation in the mouse

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Myc requires distinct E2F activities to induce S phase and apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

The paradox of E2F1: oncogene and tumor suppressor gene.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

pRb and E2f-1 in mouse development and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

Regulation of BRCA1 expression by the Rb-E2F pathway.

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

p53 down-regulates CHK1 through p21 and the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016/S0304-419X(02)50051-3

7 January 2021

10.1016/S0304-419X(02)00051-3

Identifiers

DOI

1 reference

3 August 2017

1 reference