(Q34605205)

3 August 2017

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title

MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis (English)

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3 August 2017

Craig RW

1

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3 August 2017

publication date

1 April 2002

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3 August 2017

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3 August 2017

volume

16

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3 August 2017

issue

4

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3 August 2017

page(s)

444-454

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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Improved coupling between proliferation-arrest and differentiation-induction in ML-1 human myeloblastic leukemia cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

MCL-1, a member of the BLC-2 family, is induced rapidly in response to signals for cell differentiation or death, but not to signals for cell proliferation

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

GM-CSF rescues TF-1 cells from growth factor withdrawal-induced, but not differentiation-induced apoptosis: the role of BCL-2 and MCL-1.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Antiapoptotic Action of 1,25-Dihydroxyvitamin D3Is Associated with Increased Mitochondrial MCL-1 and RAF-1 Proteins and Reduced Release of Cytochrome c

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Selective inhibition of apoptosis by TPA-induced differentiation of U937 leukemic cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Expression of the antiapoptotic MCL1 gene product is regulated by a mitogen activated protein kinase-mediated pathway triggered through microtubule disruption and protein kinase C.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Antisense inhibition of BCL-2 expression induces retinoic acid-mediated cell death during differentiation of human NT2N neurons

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

EAT/mcl-1 expression in the human embryonal carcinoma cells undergoing differentiation or apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Involvement of EAT/mcl-1, an anti-apoptotic bcl-2-related gene, in murine embryogenesis and human development

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Regulation of lymphocyte survival by the bcl-2 gene family

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Human eosinophils express bcl-2 family proteins: modulation of Mcl-1 expression by IFN-gamma

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Effect of IL-5, glucocorticoid, and Fas ligation on Bcl-2 homologue expression and caspase activation in circulating human eosinophils

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Expression of Bcl-2 and Its Homologues in Human Eosinophils

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

IL-5 but not interferon-gamma (IFN-gamma) inhibits eosinophil apoptosis by up-regulation of bcl-2 expression

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

The high-affinity IgE receptor (FcepsilonRI) blocks apoptosis in normal human monocytes

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Bcl-XL expression correlates with primary macrophage differentiation, activation of functional competence, and survival and results from synergistic transcriptional activation by Ets2 and PU.1.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Reversal of EBV Immortalization Precedes Apoptosis in IL-6–Induced Human B Cell Terminal Differentiation

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Interferon alpha extends the survival of human myeloma cells through an upregulation of the Mcl-1 anti-apoptotic molecule

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Mcl-1--just another antiapoptotic Bcl-2 Homolog?

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Involvement of EAT/mcl-1, a bcl-2 related gene, in the apoptotic mechanisms underlying human placental development and maintenance

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Induction of BCL2 family member MCL1 as an early response to DNA damage.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

The EAT/mcl-1 gene, an inhibitor of apoptosis, is up-regulated in the early stage of acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Creation of human tumour cells with defined genetic elements

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Antiapoptosis potential of bcl-2 oncogene by dephosphorylation

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Inactivation of Bcl-2 by phosphorylation

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. analysis of apoptosis and cell death.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are correlated with in vivo chemoresistance.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

From bench to clinic with apoptosis-based therapeutic agents

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Human Bcl-2 antisense therapy for lymphomas

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Inhibition of progression to androgen-independence by combined adjuvant treatment with antisense BCL-XL and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Antisense-mediated inhibition of the bcl-2 gene induces apoptosis in human malignant glioma

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Antitumor effect of bcl-2 antisense phosphorothioate oligodeoxynucleotides on human renal-cell carcinoma cells in vitro and in mice

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Preparation and evaluation of tumor-targeting peptide-oligonucleotide conjugates

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Social controls on cell survival and cell death

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2402416

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402416

1 reference

Dimensions Publication ID

3 August 2017

1037672460

0 references

1 reference