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Pharmacological inhibitors of MAPK pathways.
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1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
Pharmacological inhibitors of MAPK pathways
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
main subject
pharmacology
1 reference
based on heuristic
inferred from title
author
Melanie H. Cobb
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
author name string
Jessie M English
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
publication date
1 January 2002
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
published in
Trends in Pharmacological Sciences
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stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
volume
23
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
issue
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
page(s)
40-45
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
cites work
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal Transduction through MAP Kinase Cascades
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A synthetic inhibitor of the mitogen-activated protein kinase cascade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
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inferred from DOI database lookup
Initial sequencing and analysis of the human genome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Sequence of the Human Genome
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of p38 MAP kinase as a therapeutic strategy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
How MAP kinases are regulated
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Active and inactive protein kinases: structural basis for regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural analysis of receptor tyrosine kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of p38 mitogen-activated protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of mitogen-activated protein kinase p38 at 2.1-A resolution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis of inhibitor selectivity in MAP kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular basis for p38 protein kinase inhibitor specificity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specificity and mechanism of action of some commonly used protein kinase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic mechanism and ATP-binding site reactivity of p38gamma MAP kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of anticancer drugs targeting the MAP kinase pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacologic inhibitors of MKK1 and MKK2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential MAPK pathways utilized for HGF- and EGF-dependent renal epithelial morphogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The discovery of potent cRaf1 kinase inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016/S0165-6147(00)01865-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0165-6147(00)01865-4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
PubMed publication ID
11804650
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11804650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11804650 AND SRC:MED&resulttype=core&format=json
retrieved
6 December 2019
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