(Q34488136)

2 August 2017

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title

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. (English)

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Ras homolog enriched in brain Dmel_CG1081

2 August 2017

main subject

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GOA release 2020-03-11

author name string

Sara C Kozma

series ordinal

1

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2 August 2017

George Thomas

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

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2 August 2017

volume

24

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2 August 2017

issue

1

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2 August 2017

page(s)

65-71

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Size control in animal development

2 August 2017

cites work

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From small flies come big discoveries about size control

21 January 2018

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The beauty of small flies.

21 January 2018

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Size control: cell proliferation does not equal growth

21 January 2018

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Genetic control of cell size at cell division in yeast

21 January 2018

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Coordination of growth with cell division in the yeast Saccharomyces cerevisiae

21 January 2018

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Coordination of Growth and Cell Division in the Drosophila Wing

21 January 2018

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Oncogenic kinase signalling

21 January 2018

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Genetic control of cell size

21 January 2018

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

21 January 2018

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

21 January 2018

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Drosophila S6 kinase: a regulator of cell size

21 January 2018

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Signaling by distinct classes of phosphoinositide 3-kinases

21 January 2018

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

21 January 2018

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

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Phosphorylation and activation of p70s6k by PDK1

21 January 2018

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

21 January 2018

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Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

21 January 2018

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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

21 January 2018

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Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

21 January 2018

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TOR, a central controller of cell growth

21 January 2018

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Regulation of translation initiation by FRAP/mTOR

21 January 2018

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DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

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HEAT repeats in the Huntington's disease protein

21 January 2018

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

21 January 2018

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4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase

21 January 2018

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Ribosomal S6 kinase signaling and the control of translation

21 January 2018

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Multiple independent inputs are required for activation of the p70 S6 kinase

21 January 2018

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Structural and functional analysis of pp70S6k

21 January 2018

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Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

21 January 2018

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The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

21 January 2018

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The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

21 January 2018

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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

21 January 2018

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Regulation of cellular growth by the Drosophila target of rapamycin dTOR

21 January 2018

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The genetic basis of tuberous sclerosis

21 January 2018

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Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

21 January 2018

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Tuberous Sclerosis Gene 2 Product Modulates Transcription Mediated by Steroid Hormone Receptor Family Members

21 January 2018

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

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Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

21 January 2018

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Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

21 January 2018

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Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

21 January 2018

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

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Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

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Pancreatic beta-cell growth and diabetes mellitus

21 January 2018

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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

21 January 2018

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An encore for ribosome biogenesis in the control of cell proliferation

21 January 2018

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Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

21 January 2018

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

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Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily

21 January 2018

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Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

21 January 2018

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Lipid-Regulated Kinases: Some Common Themes at Last

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/BIES.10031

1 reference

2 August 2017

1 reference