(Q34360157)

1 August 2017

title

Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice (English)

1 reference

1 August 2017

Cho-Rok Jung

1

1 reference

1 August 2017

Jung Hwa Lim

2

1 reference

1 August 2017

Yoonjung Choi

3

1 reference

1 August 2017

Dae-Ghon Kim

4

1 reference

1 August 2017

Koo Jeong Kang

5

1 reference

1 August 2017

Seung-Moo Noh

6

1 reference

1 August 2017

Dong-Soo Im

7

1 reference

1 August 2017

language of work or name

English

0 references

publication date

8 November 2010

1 reference

full work available at URL

1 August 2017

http://www.jci.org/articles/view/42674/files/pdf

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21060154/pdf/?tool=EBI

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21060154/?tool=EBI

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

http://www.jci.org/cgi/content/abstract/120/12/4493

22 August 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

http://www.jci.org/cgi/content/full/120/12/4493

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

http://www.jci.org/cgi/reprint/120/12/4493.pdf

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

https://europepmc.org/articles/PMC2993588

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

https://europepmc.org/articles/PMC2993588?pdf=render

22 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

https://doi.org/10.1172/jci42674

22 August 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21060154

Journal of Clinical Investigation

22 August 2024

published in

1 reference

1 August 2017

volume

120

1 reference

1 August 2017

issue

12

1 reference

1 August 2017

page(s)

4493-4506

1 reference

Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development

1 August 2017

cites work

1 reference

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ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

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6 July 2018

Modes of p53 regulation

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MicroRNA-125b is a novel negative regulator of p53.

6 July 2018

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Mdm2 and Mdm4 loss regulates distinct p53 activities

6 July 2018

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6 July 2018

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Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

6 July 2018

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Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation

6 July 2018

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6 July 2018

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Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2

6 July 2018

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The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

6 July 2018

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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

6 July 2018

1 reference

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

6 July 2018

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E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis

6 July 2018

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Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation

6 July 2018

1 reference

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KCNE2, a down-regulated gene identified by in silico analysis, suppressed proliferation of gastric cancer cells

6 July 2018

1 reference

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Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells

6 July 2018

1 reference

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LIM mineralization protein-1 potentiates bone morphogenetic protein responsiveness via a novel interaction with Smurf1 resulting in decreased ubiquitination of Smads

6 July 2018

1 reference

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Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

6 July 2018

1 reference

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Tumor suppression and normal aging in mice with constitutively high p53 activity

6 July 2018

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Mdm2 in growth signaling and cancer

6 July 2018

1 reference

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HDM2 phosphorylation by MAPKAP kinase 2.

6 July 2018

1 reference

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A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

6 July 2018

1 reference

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6 July 2018

1 reference

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p53-independent functions of MDM2.

6 July 2018

1 reference

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

6 July 2018

1 reference

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HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

6 July 2018

1 reference

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E2F and Ras Synergize in Transcriptionally Activating p14ARFExpression

6 July 2018

1 reference

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The p53-Mdm2 module and the ubiquitin system.

6 July 2018

1 reference

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Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing

6 July 2018

1 reference

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Phosphorylation of HDM2 by Akt.

6 July 2018

1 reference

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Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage

6 July 2018

1 reference

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

6 July 2018

1 reference

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The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

6 July 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

The LIM domain: regulation by association

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Adenovirus-mediated p53 tumor suppressor gene therapy against subcutaneous HuH7 hepatoma cell line nodule of nude mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

The PDZ domain of the LIM protein enigma binds to beta-tropomyosin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

The MDM2 gene amplification database

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Regulation of p53 stability by Mdm2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Mdm2 promotes the rapid degradation of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Protein-protein interaction of zinc finger LIM domains with protein kinase C

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Specificity of LIM domain interactions with receptor tyrosine kinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

mdm2 expression is induced by wild type p53 activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

The p53-mdm-2 autoregulatory feedback loop

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

WAF1, a potential mediator of p53 tumor suppression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Induction of liver growth in normal mice by infusion of hepatocyte growth factor/scatter factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Mapping of the p53 and mdm-2 Interaction Domains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

P53-protein accumulation and MDM2-protein overexpression in gastric carcinomas. No apparent correlation with survival.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993588

Altered patterns of MDM2 and TP53 expression in human bladder cancer

27 October 2018

1 reference

12 December 2020

A molecular and immunohistochemical study of the MDM2 protein isoforms and p53 gene product in bronchogenic carcinoma

1 reference

12 December 2020

Protein expression of MDM2 and its clinicopathological relationships in human hepatocellular carcinoma

1 reference

12 December 2020

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

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12 December 2020

Identifiers

DOI

10.1172/JCI42674

1 reference

1 August 2017

1 reference

1 August 2017

1 reference