(Q34277794)

1 August 2017

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title

Farnesyltransferase inhibitors: potential role in the treatment of cancer (English)

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1 August 2017

Cox AD

1

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1 August 2017

publication date

1 January 2001

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1 August 2017

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1 August 2017

volume

61

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1 August 2017

issue

6

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1 August 2017

page(s)

723-732

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Suppression of mevalonate pathway activities by dietary isoprenoids: protective roles in cancer and cardiovascular disease

1 August 2017

cites work

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12 December 2020

Regulation of the mevalonate pathway

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12 December 2020

Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

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12 December 2020

A Farnesyl-Protein Transferase Inhibitor Induces p21 Expression and G1 Block in p53 Wild Type Tumor Cells

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12 December 2020

Altered growth of human colon cancer cell lines disrupted at activated Ki-ras

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12 December 2020

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956

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12 December 2020

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

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12 December 2020

Protein isoprenylation in suspension-cultured tobacco cells

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12 December 2020

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

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12 December 2020

The Ras branch of small GTPases: Ras family members don't fall far from the tree

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12 December 2020

GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells

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12 December 2020

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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12 December 2020

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

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12 December 2020

Promising new developments in cancer chemotherapy

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12 December 2020

Prevention and therapy of cancer by dietary monoterpenes

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12 December 2020

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

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12 December 2020

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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12 December 2020

Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors.

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12 December 2020

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?

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12 December 2020

Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells

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12 December 2020

The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS

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12 December 2020

Protein lipidation in cell signaling

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12 December 2020

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

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12 December 2020

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

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12 December 2020

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

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12 December 2020

Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer

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12 December 2020

Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents

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12 December 2020

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice

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12 December 2020

Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment.

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12 December 2020

ras oncogenes in human cancer: a review

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12 December 2020

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

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12 December 2020

Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells

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12 December 2020

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor

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12 December 2020

Farnesyltransferase inhibitors: targeting the molecular basis of cancer

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12 December 2020

The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts

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12 December 2020

RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

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12 December 2020

Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes

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12 December 2020

Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

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12 December 2020

Novel isoprenylated proteins identified by an expression library screen.

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12 December 2020

Protein prenyl transferase activities of Plasmodium falciparum

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12 December 2020

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

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12 December 2020

Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss.

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12 December 2020

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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12 December 2020

Protein prenylation in spinach chloroplasts

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12 December 2020

Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

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12 December 2020

Potential molecular targets for manipulating the radiation response

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12 December 2020

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine

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12 December 2020

Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

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12 December 2020

Inhibition of corneal inflammation by the topical use of Ras farnesyltransferase inhibitors: selective inhibition of macrophage localization.

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12 December 2020

10.2165/00003495-200161060-00002

Identifiers

DOI

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Dimensions Publication ID

1 August 2017

1036595102

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