(Q34263452)

1 August 2017

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title

Antigen decoding by T lymphocytes: from synapses to fate determination (English)

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1 August 2017

2

Sallusto F

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1 August 2017

Lanzavecchia A

1

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1 August 2017

language of work or name

English

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publication date

1 June 2001

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1 August 2017

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1 August 2017

volume

2

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1 August 2017

issue

6

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1 August 2017

page(s)

487-492

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The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

1 August 2017

cites work

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The immunological synapse.

21 January 2018

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

21 January 2018

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Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface

21 January 2018

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The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

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T cell activation determined by T cell receptor number and tunable thresholds.

21 January 2018

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Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor

21 January 2018

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Ligand recognition by alpha beta T cell receptors

21 January 2018

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

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Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering

21 January 2018

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The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

21 January 2018

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Dissociation of Intracellular Signaling Pathways in Response to Partial Agonist Ligands of the T Cell Receptor

21 January 2018

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Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples

21 January 2018

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Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

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A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

21 January 2018

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The structure and ligand interactions of CD2: implications for T-cell function

21 January 2018

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Making the T cell receptor go the distance: a topological view of T cell activation

21 January 2018

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Dependence of T cell antigen recognition on the dimensions of an accessory receptor-ligand complex

21 January 2018

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Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

21 January 2018

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CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

21 January 2018

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Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

21 January 2018

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Membrane Compartmentation Is Required for Efficient T Cell Activation

21 January 2018

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Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

21 January 2018

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Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor

21 January 2018

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Information transfer at the immunological synapse.

21 January 2018

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Differential clustering of CD4 and CD3zeta during T cell recognition

21 January 2018

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Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation

21 January 2018

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Molecular characterization of the di-leucine-based internalization motif of the T cell receptor

21 January 2018

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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

21 January 2018

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The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

21 January 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

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On the dynamics of TCR:CD3 complex cell surface expression and downmodulation

21 January 2018

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The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

21 January 2018

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Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors

21 January 2018

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TCR-Mediated internalization of peptide-MHC complexes acquired by T cells

21 January 2018

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T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells

21 January 2018

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

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CD28 affects the earliest signaling events generated by TCR engagement

21 January 2018

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Requirements for peptide-induced T cell receptor downregulation on naive CD8 T cells

21 January 2018

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Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells

21 January 2018

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Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

21 January 2018

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

21 January 2018

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The interleukin-2 T-cell system: a new cell growth model.

21 January 2018

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Contingent genetic regulatory events in T lymphocyte activation

21 January 2018

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Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling

21 January 2018

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A cellular calculus for signal integration by T cells

21 January 2018

1 reference

Macrophage-lymphocyte interaction. II. Antigen-mediated physical interactions between immune guinea pig lymph node lymphocytes and syngeneic macrophages

21 January 2018

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Accessory cell-T lymphocyte interactions. Antigen-dependent and -independent clustering

21 January 2018

1 reference

Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential

21 January 2018

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Interaction of T cells with APCs: the serial encounter model

21 January 2018

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Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex

21 January 2018

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Acquisition of lymphokine-producing phenotype by CD4 T cells

21 January 2018

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Functional diversity of helper T lymphocytes

21 January 2018

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Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

21 January 2018

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The role of chemokine receptors in primary, effector, and memory immune responses

21 January 2018

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

21 January 2018

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Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells

21 January 2018

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Migration and function of antigen-primed nonpolarized T lymphocytes in vivo

21 January 2018

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Visualizing the generation of memory CD4 T cells in the whole body

21 January 2018

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A transgenic mouse model to analyze CD8( ) effector T cell differentiation in vivo

21 January 2018

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Preferential localization of effector memory cells in nonlymphoid tissue

21 January 2018

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Skewed maturation of memory HIV-specific CD8 T lymphocytes

21 January 2018

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Early programming of T cell populations responding to bacterial infection

21 January 2018

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Immunological memory and protective immunity: understanding their relation

21 January 2018

1 reference

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8 T Cells

21 January 2018

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Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice

21 January 2018

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Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease

21 January 2018

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CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs

21 January 2018

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In vivo detection of dendritic cell antigen presentation to CD4( ) T cells.

21 January 2018

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The development, maturation, and turnover rate of mouse spleen dendritic cell populations

21 January 2018

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T cells compete for access to antigen-bearing antigen-presenting cells

21 January 2018

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Visualizing T cell competition for peptide/MHC complexes: a specific mechanism to minimize the effect of precursor frequency

21 January 2018

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Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses.

21 January 2018

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Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells

21 January 2018

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Distinct patterns and kinetics of chemokine production regulate dendritic cell function.

21 January 2018

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Antigen-specific development of primary and memory T cells in vivo

21 January 2018

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Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

21 January 2018

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From TCR Engagement to T Cell Activation

21 January 2018

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

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Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates

21 January 2018

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7 January 2021

Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells

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7 January 2021

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

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7 January 2021

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

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7 January 2021

T lymphocyte costimulation mediated by reorganization of membrane microdomains

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7 January 2021

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

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7 January 2021

Agonist-induced T cell receptor down-regulation: molecular requirements and dissociation from T cell activation

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7 January 2021

Activation-induced ubiquitination of the T cell antigen receptor

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7 January 2021

Activation of the Lck Tyrosine Kinase Targets Cell Surface T Cell Antigen Receptors for Lysosomal Degradation

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7 January 2021

A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies

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7 January 2021

Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation

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7 January 2021

Duration of TCR stimulation determines costimulatory requirement of T cells

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7 January 2021

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

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7 January 2021

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

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7 January 2021

Memory CD8 T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

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7 January 2021

Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo

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7 January 2021

Anatomical origin of dendritic cells determines their life span in peripheral lymph nodes

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7 January 2021

T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens

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7 January 2021

Identifiers

DOI

10.1038/88678

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1 August 2017

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