(Q34088387)

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The age of cancer

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Europe PubMed Central

PubMed publication ID

30 July 2017

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Europe PubMed Central

The age of cancer. (English)

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Europe PubMed Central

PubMed publication ID

30 July 2017

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DePinho RA

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Europe PubMed Central

PubMed publication ID

30 July 2017

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publication date

1 November 2000

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Europe PubMed Central

PubMed publication ID

30 July 2017

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Europe PubMed Central

PubMed publication ID

30 July 2017

408

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Europe PubMed Central

PubMed publication ID

30 July 2017

6809

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Europe PubMed Central

PubMed publication ID

30 July 2017

248-254

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Molecular themes in oncogenesis

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The clonal evolution of tumor cell populations

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Genetic alterations during colorectal-tumor development

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Karyotypic evolution in human malignant melanoma

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Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

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Aging: a theory based on free radical and radiation chemistry

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Oxidants, antioxidants, and the degenerative diseases of aging

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A statistical model to estimate variance in long term-low dose mutation assays: testing of the model in a human lymphoblastoid mutation assay.

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The age distribution of cancer and a multi-stage theory of carcinogenesis

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How many mutations are required for tumorigenesis? Implications from human cancer data

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The Hallmarks of Cancer

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Lessons from hereditary colorectal cancer

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Genetic instability in colorectal cancers

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Genome changes and gene expression in human solid tumors

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The cat and mouse games that genes, viruses, and cells play

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Estimation of mutation frequencies in normal mammalian cells and the development of cancer

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Rapid accumulation of genome rearrangements in liver but not in brain of old mice

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Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

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Chromosome Aberrations in Liver Cells in Relation to the Somatic Mutation Theory of Aging

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Mitotic misregulation and human aging

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The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

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Change of Human Chromosome Count Distributions with Age: Evidence for a Sex Difference

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Frequency of spontaneous chromosome aberrations in mice: effects of age.

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The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repair capacity and increased DNA mutability

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DNA repair response in human epidermal keratinocytes from donors of different age

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DNA hypermethylation in tumorigenesis: epigenetics joins genetics

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Cancer epigenetics comes of age

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Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

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Aging, DNA methylation and cancer

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Suppression of intestinal neoplasia by DNA hypomethylation.

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CpG methylation is maintained in human cancer cells lacking DNMT1.

1 reference

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Cellular senescence: mitotic clock or culture shock?

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Solid tumor cytogenetics. Progress since 1979.

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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Telomerase activity, cell proliferation, and cancer

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Telomeres shorten during ageing of human fibroblasts

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Telomere reduction in human colorectal carcinoma and with ageing

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Telomere length predicts replicative capacity of human fibroblasts

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Hypervariable ultra-long telomeres in mice

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Developmental and tissue-specific regulation of mouse telomerase and telomere length

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Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

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Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

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Expression of mouse telomerase catalytic subunit in embryos and adult tissues.

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Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization

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Comparative genomic hybridization of ductal carcinoma in situ of the breast-evidence of multiple genetic pathways

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Comparative genomic hybridization analysis of primary colorectal carcinomas and their synchronous metastases

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Essential role of mouse telomerase in highly proliferative organs

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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Activation of telomerase in a human tumor

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Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery

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Telomere shortening in chronic liver diseases

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Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis

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Telomere length in human liver diseases

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The retinoblastoma protein and cell cycle control

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

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p53-dependent apoptosis suppresses tumor growth and progression in vivo

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1 reference

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Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

1 reference

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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Creation of human tumour cells with defined genetic elements

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Flipping the oncogene switch: illumination of tumor maintenance and regression

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Essential role for oncogenic Ras in tumour maintenance

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Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

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Role of mesenchymal-epithelial interactions in mammary gland development

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Microarray analysis of replicative senescence

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Aging and cancer: the double-edged sword of replicative senescence

1 reference

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

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MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

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Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

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The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

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DNA methylation: past, present and future directions

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Cancer and aging: from the kinetics of biological parameters to the kinetics of cancer incidence and mortality.

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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity

1 reference

15 December 2024

https://opencitations.net/index/api/v1/citations/10.1002/J.1460-2075.1992.TB05245.X

Identifiers

10.1038/35041694

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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https://api.fatcat.wiki/v0/release/oocaf3ql6fd4tidv3oo3txiauq

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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