(Q33937947)

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Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator

scientific article published on July 1, 1992

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30 July 2017

Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator (English)

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30 July 2017

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E. Jacquet

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17 October 2022

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M. Y. Mistou

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P. Poullet

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17 October 2022

H. Rensland

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P. Gideon

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17 October 2022

I. Schlichting

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A. Wittinghofer

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A. Parmeggiani

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17 October 2022

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1 July 1992

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30 July 2017

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17 October 2022

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1628612/?tool=EBI

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17 October 2022

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17 October 2022

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17 October 2022

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002/j.1460-2075.1992.tb05303.x

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10.1002/J.1460-2075.1992.TB05303.X

https://api.crossref.org/works/10.1002/J.1460-2075.1992.TB05303.X

17 October 2022

http://onlinelibrary.wiley.com/wol1/doi/10.1002/j.1460-2075.1992.tb05303.x/fullpdf

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17 October 2022

The EMBO Journal

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30 July 2017

11

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30 July 2017

7

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30 July 2017

2391-2397

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Europe PubMed Central

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30 July 2017

Analysis of the transforming potential of the human H-ras gene by random mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Characterization of the elongation factors from calf brain. 2. Functional properties of EF-1 alpha, the action of physiological ligands and kirromycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Purification of ras GTPase activating protein from bovine brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Yeast mutants temperature-sensitive for growth after random mutagenesis of the chromosomal RAS2 gene and deletion of the RAS1 gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The C-terminal part of a gene partially homologous to CDC 25 gene suppresses the cdc25-5 mutation in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Ras interaction with the GTPase-activating protein (GAP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

C-terminal truncation of p21H preserves crucial kinetic and structural properties.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

A cytosolic protein catalyzes the release of GDP from p21ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Purification of a factor capable of stimulating the guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small molecular mass G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The GTPase superfamily: a conserved switch for diverse cell functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Identification of a nucleotide exchange-promoting activity for p21ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

GTPase domains of ras p21 oncogene protein and elongation factor Tu: analysis of three-dimensional structures, sequence families, and functional sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The ras protein family: evolutionary tree and role of conserved amino acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The COOH-domain of the product of the Saccharomyces cerevisiae SCD25 gene elicits activation of p21-ras proteins in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Role of glycine-82 as a pivot point during the transition from the inactive to the active form of the yeast Ras2 protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The GTPase superfamily: conserved structure and molecular mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

p21 with a phenylalanine 28----leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The residues of Ras and Rap proteins that determine their GAP specificities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The structure of Ras protein: a model for a universal molecular switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

5 July 2018

Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

29 October 2018

Different kinetic properties of the two mutants, RAS2Ile152 and RAS2Val19, that suppress the CDC25 requirement in RAS/adenylate cyclase pathway in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

29 October 2018

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=556713

29 October 2018

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the C-terminal region of smg p21, a ras p21-like small GTP-binding protein, in membrane and smg p21 GDP/GTP exchange protein interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of ras proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystallization and preliminary X-ray analysis of the human c-H-ras-oncogene product p21 complexed with GTP analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of the kinetic mechanism of elongation factor Ts

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homologous activators of ras in fission and budding yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Saccharomyces cerevisiae CDC25 gene product is a 180 kDa polypeptide and is associated with a membrane fraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/1628612

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/J.1460-2075.1992.TB05303.X

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1628612

17 October 2022

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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