(Q33834603)

29 July 2017

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title

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition (English)

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29 July 2017

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Dresser GK

1

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29 July 2017

Spence JD

series ordinal

2

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29 July 2017

Bailey DG

series ordinal

3

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29 July 2017

publication date

1 January 2000

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Clinical Pharmacokinetics

29 July 2017

published in

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29 July 2017

volume

38

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29 July 2017

issue

1

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29 July 2017

page(s)

41-57

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Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test

29 July 2017

cites work

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12 December 2020

Effects of grapefruit juice ingestion--pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men.

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12 December 2020

Carbamazepine drug interactions

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12 December 2020

Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses*

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12 December 2020

Drug interactions with grapefruit: whose responsibility is it to warn the public?

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12 December 2020

Mibefradil: a new class of calcium-channel antagonists

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12 December 2020

CYP3A gene expression in human gut epithelium

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12 December 2020

Drug points: severe ergotism associated with interaction between ritonavir and ergotamine

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12 December 2020

Pharmacokinetics of ergotamine in healthy volunteers following oral and rectal dosing

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12 December 2020

ACC/AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology/American Heart Association

1 reference

12 December 2020

Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability

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12 December 2020

A potentially hazardous interaction between erythromycin and midazolam

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12 December 2020

Cyclosporine-ketoconazole interaction. Long-term follow-up and preliminary results of a randomized trial

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12 December 2020

Erythromycin-felodipine interaction

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12 December 2020

A review of erythromycin-induced malignant tachyarrhythmia--torsade de pointes. A case report

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12 December 2020

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

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12 December 2020

Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

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12 December 2020

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

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12 December 2020

Influence of grapefruit juice on the pharmacokinetics of a slow release nifedipine formulation

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12 December 2020

Clarithromycin-carbamazepine interaction: a case report

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12 December 2020

The effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam

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12 December 2020

Effect of grapefruit juice on cyclosporine pharmacokinetics in renal transplant patients

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12 December 2020

Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin

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12 December 2020

Interaction of citrus juices with felodipine and nifedipine

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12 December 2020

Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients

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12 December 2020

Interaction between cyclosporine and grapefruit juice requires long-term ingestion in stable renal transplant recipients

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12 December 2020

Interaction between grapefruit juice and midazolam in humans*

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12 December 2020

Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram

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12 December 2020

Lovastatin and rhabdomyolysis

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12 December 2020

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12 December 2020

Coadministration of nefazodone and benzodiazepines: IV. A pharmacokinetic interaction study with lorazepam

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12 December 2020

Interactions of HIV protease inhibitors with ATP-dependent drug export proteins

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12 December 2020

Increased carbamazepine plasma concentrations after fluoxetine coadministration

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12 December 2020

Pharmacological insights from P-glycoprotein knockout mice

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12 December 2020

Pharmacokinetic interaction between cyclosporine and the dihydropyridine calcium antagonist felodipine

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12 December 2020

Nefazodone-induced carbamazepine toxicity

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12 December 2020

Grapefruit juice-terfenadine single-dose interaction: magnitude, mechanism, and relevance

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12 December 2020

Plasma concentration--effect relationships for felodipine: a meta analysis

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12 December 2020

Prolongation of the QT interval related to cisapride-diltiazem interaction

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12 December 2020

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?

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12 December 2020

Torsades de pointes after terfenadine-itraconazole interaction

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12 December 2020

Erythromycin effects on multiple-dose carbamazepine kinetics

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12 December 2020

Cisapride and fatal arrhythmia

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12 December 2020

Bioavailability of sublingual ergotamine

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12 December 2020

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

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12 December 2020

Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance

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12 December 2020

Lack of interaction of erythromycin with temazepam

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12 December 2020

Low biological availability of ergotamine tartrate after oral dosing in cluster headache

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12 December 2020

Combined use of astemizole and ketoconazole resulting in torsade de pointes

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12 December 2020

Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers

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12 December 2020

Interaction between erythromycin and nitrazepam in healthy volunteers

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12 December 2020

Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6).

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12 December 2020

Effect of route of administration of fluconazole on the interaction between fluconazole and midazolam

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12 December 2020

Absence of pharmacokinetic interaction between amiodarone and lidocaine

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12 December 2020

Interaction between midazolam and clarithromycin: comparison with azithromycin

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12 December 2020

Mechanism-based enzyme inactivators

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12 December 2020

Ketoconazole and fluconazole drug interactions

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12 December 2020

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12 December 2020

Effect of itraconazole on the pharmacokinetics of atorvastatin

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12 December 2020

Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin

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12 December 2020

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

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12 December 2020

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

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12 December 2020

Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors

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12 December 2020

Interaction between cyclosporine and fluconazole in renal allograft recipients

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12 December 2020

The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients

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12 December 2020

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

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12 December 2020

The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans

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12 December 2020

Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations

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12 December 2020

Corrections to the nifedipine meta-analysis

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12 December 2020

Grapefruit juice alters the systemic bioavailability and cardiac repolarization of terfenadine in poor metabolizers of terfenadine

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12 December 2020

Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences

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12 December 2020

Torsades de Pointes after treatment with terfenadine and ketoconazole

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12 December 2020

Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects

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12 December 2020

Expression and localization of CYP3A4 and CYP3A5 in human lung

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12 December 2020

Possible interaction between sildenafil and HIV combination therapy

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12 December 2020

FK 506/fluconazole interaction enhances FK 506 nephrotoxicity

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12 December 2020

Cytochrome P-450 3A4: regulation and role in drug metabolism

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12 December 2020

First-pass metabolism of midazolam by the human intestine.

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12 December 2020

Dose of midazolam should be reduced during diltiazem and verapamil treatments

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12 December 2020

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole

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12 December 2020

Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir

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12 December 2020

Influence of grapefruit juice on cisapride pharmacokinetics

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12 December 2020

Torsades de pointes induced by erythromycin and terfenadine

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12 December 2020

Increase in cerivastatin systemic exposure after single and multiple dosing in cyclosporine-treated kidney transplant recipients

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12 December 2020

Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid*

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12 December 2020

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12 December 2020

Carbamazepine neurotoxic reaction after administration of diltiazem

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12 December 2020

Drug-induced torsades de pointes in one patient with congenital long QT syndrome

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12 December 2020

Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

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12 December 2020

Interaction between sildenafil and HIV-1 combination therapy

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12 December 2020

In vitro and in vivo drug interactions involving human CYP3A

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12 December 2020

Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers

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12 December 2020

Pharmacokinetic overview of oral second-generation H1 antihistamines.

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12 December 2020

Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics

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12 December 2020

Interaction between grapefruit juice and diazepam in humans

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12 December 2020

Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine.

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12 December 2020

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

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12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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12 December 2020

Grapefruit juice increases oral nimodipine bioavailability

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12 December 2020

Inhibition and induction of cytochrome P450 and the clinical implications

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12 December 2020

Grapefruit juice substantially increases plasma concentrations of buspirone

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12 December 2020

Torsades de pointes in two chronic renal failure patients treated with Cisapride and Clarithromycin

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12 December 2020

Dosing implications of a clinical interaction between grapefruit juice and cyclosporine and metabolite concentrations in patients with autoimmune diseases

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12 December 2020

The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin

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12 December 2020

Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist

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12 December 2020

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

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12 December 2020

The interaction of diltiazem with lovastatin and pravastatin

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12 December 2020

Fluconazole-cyclosporine interaction: a dose-dependent effect?

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12 December 2020

A case of erythromycin-induced carbamazepine toxicity

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12 December 2020

Peripheral edema due to nifedipine-itraconazole interaction: a case report

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12 December 2020

Time-course of interaction between carbamazepine and clonazepam in normal man

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12 December 2020

Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man

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12 December 2020

Sertraline does not inhibit cytochrome P450 3A-mediated drug metabolism in vivo

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12 December 2020

Interaction of fluoxetine with carbamazepine

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12 December 2020

Torsades de pointes occurring in association with terfenadine use

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12 December 2020

Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics

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12 December 2020

Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam

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12 December 2020

Verapamil-induced carbamazepine neurotoxicity. A report of two cases

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12 December 2020

Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid

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12 December 2020

Pharmacokinetics and blood pressure effects of felodipine in elderly hypertensive patients. A comparison with young healthy subjects

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12 December 2020

Sildenafil: a review of its use in erectile dysfunction

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12 December 2020

A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in alprazolam metabolism.

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12 December 2020

Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations

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12 December 2020

Myoglobinuric renal failure due to long-standing lovastatin therapy in a patient with pre-existing chronic renal insufficiency

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12 December 2020

Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients

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12 December 2020

Interaction between carbamazepine and fluvoxamine

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12 December 2020

Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene

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12 December 2020

[Carbamazepine poisoning caused by carbamazepine-erythromycin interaction]

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12 December 2020

Nifedipine. Dose-related increase in mortality in patients with coronary heart disease

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12 December 2020

Precipitation of acute ergotism by triacetyloleandomycin

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12 December 2020

Ketoconazole to reduce the need for cyclosporine after cardiac transplantation

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12 December 2020

The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice

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12 December 2020

Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice

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12 December 2020

Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction.

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12 December 2020

Torsade de pointes induced by cisapride/clarithromycin interaction

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12 December 2020

Effects of liver diseases on drug metabolism.

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12 December 2020

Carbamazepine neurotoxicity precipitated by diltiazem

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12 December 2020

Pravastatin-induced rhabdomyolysis in a patient with mixed connective tissue disease

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12 December 2020

P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies

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12 December 2020

Grapefruit juice-drug interactions

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12 December 2020

The effect of erythromycin on the pharmacokinetics and pharmacodynamics of zopiclone

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12 December 2020

Itraconazole greatly increases plasma concentrations and effects of felodipine.

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12 December 2020

Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin

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12 December 2020

Erythromycin-felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice*

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12 December 2020

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

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12 December 2020

Interaction of citrus juices with pranidipine, a new 1,4-dihydropyridine calcium antagonist, in healthy subjects

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12 December 2020

The pharmacology of ergotamine and dihydroergotamine

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12 December 2020

Inhibition by erythromycin of the conversion of carbamazepine to its active 10,11-epoxide metabolite

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12 December 2020

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans

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12 December 2020

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

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12 December 2020

Itraconazole interacts with felodipine

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12 December 2020

Azithromycin and terfenadine: lack of drug interaction.

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12 December 2020

Drug metabolism in end-stage liver disease. In vitro activities of some phase I and phase II enzymes

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12 December 2020

Factors affecting the absolute bioavailability of nifedipine

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12 December 2020

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG

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12 December 2020

10.2165/00003088-200038010-00003

Identifiers

DOI

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Dimensions Publication ID

29 July 2017

1025876701

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