(Q33780942)

English

The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells

scientific article

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

based on heuristic

inferred from title

author name string

A Reik

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

A Telling

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

G Zitnik

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

D Cimbora

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

E Epner

5

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

M Groudine

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

0 references

publication date

1 October 1998

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

5992-6000

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC109185/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Histone acetylation and transcriptional regulatory mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Intergenic transcription and transinduction of the human β-globin locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

The activation domain of the enhancer binding protein p45NF-E2 interacts with TAF II 130 and mediates long-range activation of the α- and β-globin gene loci in an erythroid cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

The role of insulator elements in defining domains of gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Expression of the (recombinant) endogenous immunoglobulin heavy-chain locus requires the intronic matrix attachment regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Variegated expression of a globin transgene correlates with chromatin accessibility but not methylation status.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Regulation of beta-globin gene expression: straightening out the locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the beta-globin locus control region. Domain opening and synergism between HS2 and HS3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

An enhancer/locus control region is not sufficient to open chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Replication structure of the human beta-globin gene domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Enhancers increase the probability but not the level of gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Targeted inactivation of the major positive regulatory element (HS-40) of the human alpha-globin gene locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Participation of the human beta-globin locus control region in initiation of DNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

beta-globin transcript found in induced murine erythroleukemia cells is homologous to the beta h0 and beta h1 genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

The "beta-like-globin" gene domain in human erythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Nuclear scaffold attachment sites in the human globin gene complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Stable propagation of the active transcriptional state of an immunoglobulin mu gene requires continuous enhancer function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

The FLP recombinase of the yeast 2-micron plasmid: characterization of its recombination site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Determination of DNA sequences essential for FLP-mediated recombination by a novel method.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

A dominant control region from the human beta-globin locus conferring integration site-independent gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Molecular analysis of the human beta-globin locus activation region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Erythroid-specific nuclease-hypersensitive sites flanking the human beta-globin domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Synergistic enhancement of globin gene expression by activator protein-1-like proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

The proximal element of the beta globin locus control region is not functionally required in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Hypersensitive site 4 of the human beta globin locus control region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Recombinase-mediated gene activation and site-specific integration in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Murine erythroleukemia cell line GM979 contains factors that can activate silent chromosomal human gamma-globin genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Functional properties of the beta-globin locus control region in K562 erythroleukemia cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: induction leads to a reversible disruption of nucleosomes over an enhancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Transcription of the hypersensitive site HS2 enhancer in erythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Structure and function of the murine beta-globin locus control region 5' HS-3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

4 July 2018

Description and targeted deletion of 5' hypersensitive site 5 and 6 of the mouse beta-globin locus control region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

30 October 2018

Fluorochrome-labeled tyramides: use in immunocytochemistry and fluorescence in situ hybridization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

30 October 2018

Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

30 October 2018

A 5' beta-globin matrix-attachment region and the polyoma enhancer together confer position-independent transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

30 October 2018

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

30 October 2018

Physical mapping of human chromosome 17 using fragment-containing microcell hybrids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109185

30 October 2018

The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/9742116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9742116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/9742116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator

1 reference

https://pubmed.ncbi.nlm.nih.gov/9742116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Ordered NotI Fragment Map of Human Chromosome Band 11p15

1 reference

https://pubmed.ncbi.nlm.nih.gov/9742116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional enhancers act in cis to suppress position-effect variegation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9742116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locus control region function and heterochromatin-induced position effect variegation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9742116

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.18.10.5992

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q33780942&oldid=2067506515"