(Q33772649)

29 July 2017

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title

Regulation of the APC and the exit from mitosis (English)

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29 July 2017

Morgan DO

1

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29 July 2017

publication date

1 June 1999

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29 July 2017

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29 July 2017

volume

1

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29 July 2017

issue

2

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29 July 2017

page(s)

E47-53

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How proteolysis drives the cell cycle

29 July 2017

cites work

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7 January 2021

Eliminating All Obstacles: Regulated Proteolysis in the Eukaryotic Cell Cycle

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7 January 2021

Proteolytic ratchets that control progression through mitosis

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7 January 2021

SCF and APC: the Yin and Yang of cell cycle regulated proteolysis

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7 January 2021

Ubiquitin-dependent protein degradation

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7 January 2021

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis

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7 January 2021

A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

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7 January 2021

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase

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7 January 2021

TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast

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7 January 2021

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7 January 2021

Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1

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7 January 2021

Identification of BIME as a subunit of the anaphase-promoting complex

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7 January 2021

Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

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7 January 2021

Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast

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7 January 2021

Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae

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7 January 2021

Budding yeast RSI1/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit

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7 January 2021

A Novel Yeast Screen for Mitotic Arrest Mutants IdentifiesDOC1, a New Gene Involved in Cyclin Proteolysis

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7 January 2021

Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

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7 January 2021

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

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7 January 2021

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

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7 January 2021

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae

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7 January 2021

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

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7 January 2021

Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts

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7 January 2021

Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc. A mammalian homolog of CDC20/Fizzy/slp1.

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7 January 2021

Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

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7 January 2021

Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint

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7 January 2021

Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase

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7 January 2021

A WD Repeat Protein Controls the Cell Cycle and Differentiation by Negatively Regulating Cdc2/B-Type Cyclin Complexes

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7 January 2021

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex

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7 January 2021

Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast.

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7 January 2021

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

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7 January 2021

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

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7 January 2021

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p

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7 January 2021

Cut2 proteolysis required for sister-chromatid seperation in fission yeast

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7 January 2021

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast

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7 January 2021

Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis.

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7 January 2021

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

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7 January 2021

Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.

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7 January 2021

Universal control mechanism regulating onset of M-phase

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7 January 2021

The decision to enter mitosis

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7 January 2021

Mitosis in transition

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7 January 2021

Cyclin-dependent kinases: engines, clocks, and microprocessors

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7 January 2021

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

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7 January 2021

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells.

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7 January 2021

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.

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7 January 2021

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast

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7 January 2021

The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis

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7 January 2021

Temporal and spatial control of cyclin B1 destruction in metaphase

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7 January 2021

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

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7 January 2021

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

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7 January 2021

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

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7 January 2021

A Subunit of the Anaphase-Promoting Complex Is a Centromere-Associated Protein in Mammalian Cells

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7 January 2021

Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

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7 January 2021

Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation

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7 January 2021

The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells

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7 January 2021

Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase

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7 January 2021

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

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7 January 2021

PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression.

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7 January 2021

Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis

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7 January 2021

Cell cycle checkpoints: preventing an identity crisis

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7 January 2021

The spindle assembly checkpoint

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7 January 2021

The spindle checkpoint.

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7 January 2021

Budding yeast Cdc20: a target of the spindle checkpoint.

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7 January 2021

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

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7 January 2021

Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores

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7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

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7 January 2021

Localization of Mad2 to kinetochores depends on microtubule attachment, not tension

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7 January 2021

Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase

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7 January 2021

The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

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7 January 2021

Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast

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7 January 2021

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.

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7 January 2021

The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1.

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7 January 2021

Phosphorylation of Sic1p by G 1 Cdk Required for Its Degradation and Entry into S Phase

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7 January 2021

Bifurcation of the mitotic checkpoint pathway in budding yeast

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7 January 2021

CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain

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7 January 2021

The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle

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7 January 2021

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5

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7 January 2021

The Activity of Cdc14p, an Oligomeric Dual Specificity Protein Phosphatase from Saccharomyces cerevisiae, Is Required for Cell Cycle Progression

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7 January 2021

Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1.

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7 January 2021

The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase

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7 January 2021

MOB1, an Essential Yeast Gene Required for Completion of Mitosis and Maintenance of Ploidy

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7 January 2021

A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae.

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7 January 2021

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation

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7 January 2021

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

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7 January 2021

Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity

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7 January 2021

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus

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7 January 2021

Polo-like kinases: positive regulators of cell division from start to finish.

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7 January 2021

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

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7 January 2021

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

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7 January 2021

Drosophila polo kinase is required for cytokinesis

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7 January 2021

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts

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7 January 2021

Robustness in simple biochemical networks

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7 January 2021

Robustness in bacterial chemotaxis

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7 January 2021

Identifiers

DOI

10.1038/10039

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Dimensions Publication ID

29 July 2017

1008891532

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