(Q33585575)

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Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies

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Europe PubMed Central

PubMed publication ID

28 July 2017

Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Lucas Doedens

1

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Europe PubMed Central

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28 July 2017

Florian Opperer

2

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Europe PubMed Central

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28 July 2017

Minying Cai

3

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Europe PubMed Central

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28 July 2017

Johannes G Beck

4

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Europe PubMed Central

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28 July 2017

Matt Dedek

5

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Europe PubMed Central

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28 July 2017

Erin Palmer

6

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Europe PubMed Central

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28 July 2017

Victor J Hruby

7

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28 July 2017

Horst Kessler

8

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28 July 2017

language of work or name

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publication date

1 June 2010

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Europe PubMed Central

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28 July 2017

Journal of the American Chemical Society

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28 July 2017

132

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28 July 2017

23

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Europe PubMed Central

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28 July 2017

8115-8128

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Europe PubMed Central

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28 July 2017

N-methylation of peptides: a new perspective in medicinal chemistry

1 reference

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Design and chemical synthesis of integrin ligands

1 reference

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Melanocortin receptors, melanotropic peptides and penile erection

1 reference

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Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor

1 reference

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Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling

1 reference

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14 July 2018

Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5

1 reference

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14 July 2018

Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs

1 reference

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Crucial role of the melanocortin receptor MC1R in experimental colitis

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Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities

1 reference

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GROMACS: fast, flexible, and free

1 reference

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Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors

1 reference

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Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic beta-amino acid

1 reference

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Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues

1 reference

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14 July 2018

Solid-phase synthesis and characterization of N-methyl-rich peptides.

1 reference

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Role of proopiomelanocortin neurons and peptides in the regulation of energy homeostasis.

1 reference

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Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity

1 reference

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Solution structures of cyclic melanocortin agonists and antagonists by NMR.

1 reference

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Reducing the duration of broadband excitation pulses using optimal control with limited RF amplitude.

1 reference

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Measurement of long range H,C couplings in natural products in orienting media: a tool for structure elucidation of natural products

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14 July 2018

Application of optimal control theory to the design of broadband excitation pulses for high-resolution NMR.

1 reference

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The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

1 reference

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14 July 2018

Binge eating as a major phenotype of melanocortin 4 receptor gene mutations

1 reference

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14 July 2018

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

1 reference

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14 July 2018

The melanocortin system

1 reference

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14 July 2018

N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity

1 reference

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14 July 2018

D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity

1 reference

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14 July 2018

Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-alpha-MSH in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895553

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Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II

1 reference

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N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

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Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents.

1 reference

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Glutamine235and Arginine272in Human Melanocortin 5 Receptor Determines Its Low Affinity to MSH

1 reference

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Melanotropic peptide receptors: membrane markers of human melanoma cells

1 reference

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14 July 2018

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1 reference

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Melanotropic peptide-conjugated beads for microscopic visualization and characterization of melanoma melanotropin receptors

1 reference

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14 July 2018

Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity.

1 reference

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Localization of ACTH receptor mRNA by in situ hybridization in mouse adrenal gland

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VMD: visual molecular dynamics

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Molecular cloning of a novel melanocortin receptor

1 reference

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Molecular cloning of a novel human melanocortin receptor

1 reference

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Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895553

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Melanotropic peptides for therapeutic and cosmetic tanning of the skin

1 reference

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Molecular cloning, expression, and characterization of a fifth melanocortin receptor

1 reference

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Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues.

1 reference

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Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R.

1 reference

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Stability of cyclosporin A in human serum

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Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units

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Multiple N-methylation by a designed approach enhances receptor selectivity

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31 October 2018

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Bradykinin analogues containing N alpha-methyl amino acids.

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10 December 2018

The Melanotropic Peptides. Conference proceedings. Rouen, France, September 6-9, 1992

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1 reference

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12 December 2020

based on heuristic

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Proceedings of the 5th International Melanocortin Meeting. August 25-28, 2002. Sunriver, Oregon, USA

1 reference

https://pubmed.ncbi.nlm.nih.gov/20496895

12 December 2020

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12 December 2020

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1 reference

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alpha-Melanotropin: the minimal active sequence in the frog skin bioassay

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Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics

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Identifiers

10.1021/JA101428M

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

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