(Q33540071)

27 July 2017

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title

CDK inhibition and cancer therapy (English)

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27 July 2017

Garrett MD

1

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27 July 2017

Fattaey A

series ordinal

2

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27 July 2017

publication date

1 February 1999

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Current Opinion in Genetics & Development

27 July 2017

published in

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27 July 2017

volume

9

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27 July 2017

issue

1

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27 July 2017

page(s)

104-111

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Regulation of CDK/cyclin complexes during the cell cycle

27 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cyclin dependent kinase regulation

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Principles of CDK regulation

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Animal cell cycles and their control

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7 January 2021

Cell cycle checkpoints: preventing an identity crisis

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7 January 2021

Viewpoint: putting the cell cycle in order

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7 January 2021

At the heart of the budding yeast cell cycle

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7 January 2021

Understanding the cell cycle

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7 January 2021

When checkpoints fail

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7 January 2021

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

A temporal and biochemical link between growth factor-activated MAP kinases, cyclin D1 induction and cell cycle entry

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

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7 January 2021

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

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7 January 2021

Chemical inhibitors of cyclin-dependent kinases

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7 January 2021

Inhibition of p53 Protein Phosphorylation by 9‐Hydroxyellipticine: A Possible Anticancer Mechanism

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7 January 2021

Cleavage inhibition in marine eggs by puromycin and 6-dimethylaminopurine.

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity.

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Inhibition of cyclin-dependent kinases by purine analogues

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

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7 January 2021

Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds

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7 January 2021

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

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7 January 2021

CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation

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https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Induction of apoptosis and regression of spontaneous dog melanoma following in vivo application of synthetic cyclin-dependent kinase inhibitor olomoucine

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cyclin-dependent kinase inhibitors block proliferation of human gastric cancer cells

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Inhibition of Pancreatic Tumor Cell Growth in Culture by p21WEF1 Recombinant Adenovirus

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

p27Kip1 overexpression causes apoptotic death of mammalian cells

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Distinct roles for cyclin-dependent kinases in cell cycle control

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

The Effect of the Cyclin-Dependent Kinase Inhibitor Olomoucine on Cell Cycle Kinetics

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Survival-promoting activity of inhibitors of cyclin-dependent kinases on primary neurons correlates with inhibition of c-Jun kinase-1

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cleavage of CDK inhibitor p21(Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Caspase 3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

The role of Cdk7 in CAK function, a retro-retrospective

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Nuclear Localization of Cyclin B1 Controls Mitotic Entry After DNA Damage

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Roles of ubiquitin-mediated proteolysis in cell cycle control

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

How proteolysis drives the cell cycle

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

The ubiquitin-mediated proteolytic pathway as a therapeutic area

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

p27/kip1 expression in human astrocytic gliomas.

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1 reference

https://api.crossref.org/works/10.1016/S0959-437X(99)80015-X

7 January 2021

10.1016/S0959-437X(99)80015-X

Identifiers

DOI

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27 July 2017

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