(Q30728721)

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

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Europe PubMed Central

PubMed publication ID

26 June 2017

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

transmembrane protein

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author name string

C Yu

1

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

S H Kim

2

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

T Ikeuchi

3

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

H Xu

4

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

L Gasparini

5

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

R Wang

6

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

S S Sisodia

7

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

language of work or name

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publication date

2 October 2001

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

26 June 2017

276

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

47

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

43756-43760

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Nuclear access and action of notch in vivo

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

A detergent-free method for purifying caveolae membrane from tissue culture cells

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

In search of gamma-secretase: presenilin at the cutting edge

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074/JBC.C100410200

21 January 2018

Identifiers

10.1074/JBC.C100410200

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 June 2017

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