(Q29818026)

1 reference

1 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

cell component

TSC1-TSC2 complex

1 reference

1 January 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

regulation of cell growth

biological process

1 reference

1 January 2018

Control of growth and organ size in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

signal transduction

1 reference

1 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

open tracheal system development

1 reference

1 January 2018

A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

response to nutrient

1 reference

1 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

negative regulation of cell population proliferation

1 reference

1 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

insulin receptor signaling pathway

1 reference

1 January 2018

Mechanisms of size control.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

determination of adult lifespan

1 reference

1 January 2018

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

positive regulation of autophagy

1 reference

1 January 2018

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

negative regulation of cell growth

Rheb fills a GAP between TSC and TOR.

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

regulation of actin cytoskeleton organization

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 reference

1 January 2018

IBA

larval midgut histolysis

1 reference

1 January 2018

Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

enteroendocrine cell differentiation

1 reference

1 January 2018

TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

intestinal stem cell homeostasis

1 reference

1 January 2018

TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

TORC1 signaling

1 reference

1 January 2018

Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

regulation of cell population proliferation

1 reference

1 January 2018

Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

regulation of phosphorylation

1 reference

1 January 2018

Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

cholesterol homeostasis

1 reference

1 January 2018

A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

positive regulation of GTPase activity

1 reference

1 January 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

negative regulation of cell size

Tor signalling in bugs, brain and brawn

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

Mechanisms of size control.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

regulation of organ growth

1 reference

1 January 2018

Mechanisms of size control.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

negative regulation of organ growth

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

negative regulation of insulin receptor signaling pathway

1 reference

1 January 2018

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

oogenesis

1 reference

1 January 2018

The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

regulation of timing of cell differentiation

1 reference

1 January 2018

Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

negative regulation of developmental growth

1 reference

1 January 2018

Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

lipid homeostasis

1 reference

1 January 2018

Specialized hepatocyte-like cells regulate Drosophila lipid metabolism.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

cellular response to hypoxia

1 reference

1 January 2018

An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

cellular response to chloroquine

1 reference

1 January 2018

Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

negative regulation of TORC1 signaling

positive regulation of TORC2 signaling

1 reference

1 January 2018

LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

regulation of terminal button organization

1 reference

1 January 2018

A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9

regulation of reactive oxygen species metabolic process

1 reference

1 January 2018

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VCC9&geneProductId=UniProtKB:Q9VCC9