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Toll-like receptors and innate immunity
scientific article (publication date: November 2001)
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title
Toll-like receptors and innate immunity
(English)
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stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
main subject
toll-like receptor
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author
Ruslan Medzhitov
series ordinal
1
object named as
Medzhitov R
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stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
language of work or name
English
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
publication date
November 2001
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stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
published in
Nature Reviews Immunology
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
volume
1
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
issue
2
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
page(s)
135-45
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
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MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex
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MyD88, an adapter protein involved in interleukin-1 signaling
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TIRAP: an adapter molecule in the Toll signaling pathway
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Toll signaling pathways in the innate immune response
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A conserved signaling pathway: the Drosophila toll-dorsal pathway
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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
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Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor
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The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
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Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
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Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
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A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
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Interactions between the cellular and humoral immune responses in Drosophila
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The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
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The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.
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A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity
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Role of Drosophila IKK gamma in a toll-independent antibacterial immune response
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Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
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Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
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Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila
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Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila
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Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
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The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
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Toll-like receptors: critical proteins linking innate and acquired immunity
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
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Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
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Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages
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CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
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inferred from DOI database lookup
Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
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7 January 2021
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inferred from DOI database lookup
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
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Crossref
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7 January 2021
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inferred from DOI database lookup
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling
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7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
The molecular mechanism of B cell activation by toll-like receptor protein RP-105
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
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Crossref
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An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells
1 reference
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based on heuristic
inferred from DOI database lookup
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
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7 January 2021
based on heuristic
inferred from DOI database lookup
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discrimination of bacterial lipoproteins by Toll-like receptor 6
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PKR; a sentinel kinase for cellular stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JNK2 and IKKbeta are required for activating the innate response to viral infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Toll-like receptor recognizes bacterial DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CpG motifs in bacterial DNA trigger direct B-cell activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transport of bacterial lipopolysaccharide to the golgi apparatus
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
The role of CpG motifs in innate immunity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of direct antimicrobial activity through mammalian toll-like receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Q24291418
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK: a kinase associated with the interleukin-1 receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TRAF6 is a signal transducer for interleukin-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unresponsiveness of MyD88-deficient mice to endotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endotoxin-induced maturation of MyD88-deficient dendritic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dendritic cells and the control of immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toll-like receptors control activation of adaptive immune responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pentraxin family of proteins interact specifically with phosphorylcholine and/or phosphorylethanolamine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Scavenger receptors in innate immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038/35100529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/35100529
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
143471
Dimensions Publication ID
1008398067
0 references
OpenCitations bibliographic resource ID
143471
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
143471
PubMed publication ID
11905821
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11905821
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
143471
ResearchGate publication ID
11458100
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